(E)-4-Methyl-2-(methyl-phenyl-amino)-8-(toluene-4-sulfonyl)-oct-2-enenitrile

Base Information

Chemical Name:(E)-4-Methyl-2-(methyl-phenyl-amino)-8-(toluene-4-sulfonyl)-oct-2-enenitrile
CAS No.:117909-46-3
Molecular Formula:C₂₃H₂₈N₂O₂S
Molecular Weight:396.554
Hs Code.:

Synonyms:(E)-4-Methyl-2-(methyl-phenyl-amino)-8-(toluene-4-sulfonyl)-oct-2-enenitrile

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Chemical Property of (E)-4-Methyl-2-(methyl-phenyl-amino)-8-(toluene-4-sulfonyl)-oct-2-enenitrile

Chemical Property:

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Technology Process of (E)-4-Methyl-2-(methyl-phenyl-amino)-8-(toluene-4-sulfonyl)-oct-2-enenitrile

There total 4 articles about (E)-4-Methyl-2-(methyl-phenyl-amino)-8-(toluene-4-sulfonyl)-oct-2-enenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 824-79-3
sodium 4-methylbenzenesulfinate

: 117909-45-2,120568-33-4
(E)-8-Bromo-4-methyl-2-(methyl-phenyl-amino)-oct-2-enenitrile

: 117909-46-3
(E)-4-Methyl-2-(methyl-phenyl-amino)-8-(toluene-4-sulfonyl)-oct-2-enenitrile

Guidance literature:: In methanol; for 6h; Ambient temperature;

Reference yield:

: 100-61-8
N-methylaniline

: 117909-46-3
(E)-4-Methyl-2-(methyl-phenyl-amino)-8-(toluene-4-sulfonyl)-oct-2-enenitrile

Guidance literature:: Multi-step reaction with 4 steps

1: 2.59 g / HCl / benzyltriethylammonium chloride / H₂O / 4 h / Ambient temperature

2: MeONa / methanol / 1 h / Ambient temperature

3: 1.) BuLi, di-isopropylamine, hexamethylphosphoric triamide / 1.) THF, hexane, -78 deg C, 45 min; 2.) THF, hexane

4: 91 percent / methanol / 6 h / Ambient temperature

With hydrogenchloride; N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium; sodium methylate; diisopropylamine; N-benzyl-N,N,N-triethylammonium chloride; In methanol; water;

Reference yield:

: 57361-03-2
(E/Z)-2-(N-Methylanilino)-2-pentennitril

: 117909-46-3
(E)-4-Methyl-2-(methyl-phenyl-amino)-8-(toluene-4-sulfonyl)-oct-2-enenitrile

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) BuLi, di-isopropylamine, hexamethylphosphoric triamide / 1.) THF, hexane, -78 deg C, 45 min; 2.) THF, hexane

2: 91 percent / methanol / 6 h / Ambient temperature

With N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium; diisopropylamine; In methanol;