4-(4-Trifluoromethylphenyl)benzylchloride

Base Information

Chemical Name:4-(4-Trifluoromethylphenyl)benzylchloride
CAS No.:454464-38-1
Molecular Formula:C14H10ClF3
Molecular Weight:270.682
Hs Code.:
DSSTox Substance ID:DTXSID10466618
Wikidata:Q82293212
Mol file:454464-38-1.mol

Synonyms:4-(4-Trifluoromethylphenyl)benzylchloride;454464-38-1;1-(chloromethyl)-4-[4-(trifluoromethyl)phenyl]benzene;4-Chloromethyl-4'-trifluoromethylbiphenyl;SCHEMBL2290365;DTXSID10466618;4-Chloromethyl-4'-trifluoromethyl-biphenyl;4-(chloromethyl)-4'-(trifluoromethyl)biphenyl;4-(chloromethyl)-4'-(trifluoromethyl)-1,1'-biphenyl

Suppliers and Price of 4-(4-Trifluoromethylphenyl)benzylchloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of 4-(4-Trifluoromethylphenyl)benzylchloride

Chemical Property:

PSA：0.00000
LogP:5.11120
XLogP3:4.8
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:270.0423125
Heavy Atom Count:18
Complexity:248

Purity/Quality:: 95% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=CC=C1CCl)C2=CC=C(C=C2)C(F)(F)F

Technology Process of 4-(4-Trifluoromethylphenyl)benzylchloride

There total 8 articles about 4-(4-Trifluoromethylphenyl)benzylchloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 457889-46-2
(4′-(trifluoromethyl)-[1,1′-biphenyl]-4-yl)methanol

: 454464-38-1
4-Chloromethyl-4'-trifluoromethyl-biphenyl

Guidance literature:: With thionyl chloride; In chloroform; at 20 ℃; for 12h;

Reference yield: 75.0%

: 128796-39-4
4-trifluoromethylphenylboronic acid

: 589-17-3
p-bromobenzyl chloride

: 454464-38-1
4-Chloromethyl-4'-trifluoromethyl-biphenyl

Guidance literature:: With palladium diacetate; caesium carbonate; tricyclohexylphosphine tetrafluoroborate; In water; toluene; at 80 ℃; for 2h; Schlenk technique; Inert atmosphere;
DOI:10.3390/molecules23020433

Reference yield:

: 5798-75-4
Ethyl 4-bromobenzoate

: 454464-38-1
4-Chloromethyl-4'-trifluoromethyl-biphenyl

Guidance literature:: Multi-step reaction with 3 steps

1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,2-dimethoxyethane; water / Inert atmosphere; Reflux

2: lithium aluminium tetrahydride / tetrahydrofuran / 0 °C

3: thionyl chloride / chloroform / 20 °C

With lithium aluminium tetrahydride; thionyl chloride; sodium carbonate; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; 1,2-dimethoxyethane; chloroform; water;