1-[5-N,N-dimethylamino-2-(2-pyridinyl)benzimidazole]-1'-α-deoxyriboside-5'-O-(4,4'-dimethoxytrityl) ether

Base Information

Chemical Name:1-[5-N,N-dimethylamino-2-(2-pyridinyl)benzimidazole]-1'-α-deoxyriboside-5'-O-(4,4'-dimethoxytrityl) ether
CAS No.:889664-41-9
Molecular Formula:C₄₀H₄₀N₄O₅
Molecular Weight:656.781
Hs Code.:

Synonyms:1-[5-N,N-dimethylamino-2-(2-pyridinyl)benzimidazole]-1'-α-deoxyriboside-5'-O-(4,4'-dimethoxytrityl) ether

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Chemical Property of 1-[5-N,N-dimethylamino-2-(2-pyridinyl)benzimidazole]-1'-α-deoxyriboside-5'-O-(4,4'-dimethoxytrityl) ether

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Technology Process of 1-[5-N,N-dimethylamino-2-(2-pyridinyl)benzimidazole]-1'-α-deoxyriboside-5'-O-(4,4'-dimethoxytrityl) ether

There total 5 articles about 1-[5-N,N-dimethylamino-2-(2-pyridinyl)benzimidazole]-1'-α-deoxyriboside-5'-O-(4,4'-dimethoxytrityl) ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 20691-71-8
5-(dimethylamino)-2-nitroaniline

: 889664-41-9
1-[5-N,N-dimethylamino-2-(2-pyridinyl)benzimidazole]-1'-α-deoxyriboside-5'-O-(4,4'-dimethoxytrityl) ether

Guidance literature:: Multi-step reaction with 5 steps

1: 80 percent / NaBH₄ / Pd/C / methanol; ethyl acetate

2: nitrobenzene / 2 h / 150 °C

3: NaH / N,N-dimethyl-acetamide / 2 h / 20 °C

4: NaOMe / methanol; CH₂Cl₂ / 1 h / 20 °C

5: 76 percent / p-N,N-dimethylaminopyridine / pyridine / 2 h / 20 °C

With dmap; sodium tetrahydroborate; sodium methylate; sodium hydride; palladium on activated charcoal; In pyridine; methanol; dichloromethane; N,N-dimethyl acetamide; ethyl acetate; nitrobenzene;
DOI:10.1021/ja0581806

Reference yield:

: 1635-61-6
5-chloro-2-nitroaniline

: 889664-41-9
1-[5-N,N-dimethylamino-2-(2-pyridinyl)benzimidazole]-1'-α-deoxyriboside-5'-O-(4,4'-dimethoxytrityl) ether

Guidance literature:: Multi-step reaction with 6 steps

1: 96 percent / K₂CO₃ / H₂O; dimethylformamide / 12 h / 150 °C

2: 80 percent / NaBH₄ / Pd/C / methanol; ethyl acetate

3: nitrobenzene / 2 h / 150 °C

4: NaH / N,N-dimethyl-acetamide / 2 h / 20 °C

5: NaOMe / methanol; CH₂Cl₂ / 1 h / 20 °C

6: 76 percent / p-N,N-dimethylaminopyridine / pyridine / 2 h / 20 °C

With dmap; sodium tetrahydroborate; sodium methylate; sodium hydride; potassium carbonate; palladium on activated charcoal; In pyridine; methanol; dichloromethane; N,N-dimethyl acetamide; water; ethyl acetate; nitrobenzene; N,N-dimethyl-formamide;
DOI:10.1021/ja0581806

Reference yield:

: 889664-39-5
5-N,N-dimethylamino-2-(2-pyridinyl)-1H-benzimidazole

: 889664-41-9
1-[5-N,N-dimethylamino-2-(2-pyridinyl)benzimidazole]-1'-α-deoxyriboside-5'-O-(4,4'-dimethoxytrityl) ether

Guidance literature:: Multi-step reaction with 3 steps

1: NaH / N,N-dimethyl-acetamide / 2 h / 20 °C

2: NaOMe / methanol; CH₂Cl₂ / 1 h / 20 °C

3: 76 percent / p-N,N-dimethylaminopyridine / pyridine / 2 h / 20 °C

With dmap; sodium methylate; sodium hydride; In pyridine; methanol; dichloromethane; N,N-dimethyl acetamide;
DOI:10.1021/ja0581806