4-cyclopropyl-N₂-{1-[trans-4-(propyloxy)cyclohexyl]-4-piperidinyl}-1,2-benzenediamine

Base Information

• Chemical Name: 4-cyclopropyl-N₂-{1-[trans-4-(propyloxy)cyclohexyl]-4-piperidinyl}-1,2-benzenediamine
• CAS No.: 950772-60-8
• Molecular Formula: C₂₃H₃₇N₃O
• Molecular Weight: 371.566

Synonyms:4-cyclopropyl-N₂-{1-[trans-4-(propyloxy)cyclohexyl]-4-piperidinyl}-1,2-benzenediamine

Chemical Property of 4-cyclopropyl-N₂-{1-[trans-4-(propyloxy)cyclohexyl]-4-piperidinyl}-1,2-benzenediamine

Chemical Property:

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Technology Process of 4-cyclopropyl-N₂-{1-[trans-4-(propyloxy)cyclohexyl]-4-piperidinyl}-1,2-benzenediamine

There total 10 articles about 4-cyclopropyl-N₂-{1-[trans-4-(propyloxy)cyclohexyl]-4-piperidinyl}-1,2-benzenediamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

N-(5-cyclopropyl-2-nitrophenyl)-1-[trans-4-(propyloxy)cyclohexyl]-4-piperidinamine (950772-59-5) → 4-cyclopropyl-N2-{1-[trans-4-(propyloxy)cyclohexyl]-4-piperidinyl}-1,2-benzenediamine (950772-60-8)

Guidance literature:

With hydrazine; nickel; In ethanol; at 20 ℃; for 2h;

Reference yield:

N-ethyl-4-piperidone (3612-18-8) → 4-cyclopropyl-N2-{1-[trans-4-(propyloxy)cyclohexyl]-4-piperidinyl}-1,2-benzenediamine (950772-60-8)

Guidance literature:

Multi-step reaction with 5 steps

1: acetone / 3 h / 0 - 30 °C

2: potassium carbonate / ethanol; water / 1 h / 80 °C / Heating / reflux

3: ammonia; hydrogen / palladium 10% on activated carbon / methanol / 18 h / 20 °C / 2585.81 Torr

4: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 80 °C

5: hydrazine / nickel / ethanol / 2 h / 20 °C

With ammonia; hydrogen; potassium carbonate; N-ethyl-N,N-diisopropylamine; hydrazine; palladium 10% on activated carbon; nickel; In methanol; ethanol; water; N,N-dimethyl-formamide; acetone;

Reference yield:

2-((1R,4R)-4-((tert-butyldimethylsilyl)oxy)cyclohexyl)isoindoline-1,3-dione (847416-23-3) → 4-cyclopropyl-N2-{1-[trans-4-(propyloxy)cyclohexyl]-4-piperidinyl}-1,2-benzenediamine (950772-60-8)

Guidance literature:

Multi-step reaction with 6 steps

1: triethylsilane; bismuth(III) bromide / acetonitrile / 0.5 h / 0 - 30 °C

2: hydrazine / ethanol / 2 h / 80 °C

3: potassium carbonate / ethanol; water / 1 h / 80 °C / Heating / reflux

4: ammonia; hydrogen / palladium 10% on activated carbon / methanol / 18 h / 20 °C / 2585.81 Torr

5: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 80 °C

6: hydrazine / nickel / ethanol / 2 h / 20 °C

With triethylsilane; ammonia; hydrogen; bismuth(III) bromide; potassium carbonate; N-ethyl-N,N-diisopropylamine; hydrazine; palladium 10% on activated carbon; nickel; In methanol; ethanol; water; N,N-dimethyl-formamide; acetonitrile;

upstream raw materials:

N-(5-cyclopropyl-2-nitrophenyl)-1-[trans-4-(propyloxy)cyclohexyl]-4-piperidinamine

N-ethyl-4-piperidone

2-((1R,4R)-4-((tert-butyldimethylsilyl)oxy)cyclohexyl)isoindoline-1,3-dione

trans-1-(4-propoxycylohexyl)-4-piperidone

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