1-benzoylpyrrolo[1,2-a]quinoline-2-carboxylic acid methyl ester

Base Information

• Chemical Name: 1-benzoylpyrrolo[1,2-a]quinoline-2-carboxylic acid methyl ester
• CAS No.: 1310066-81-9
• Molecular Formula: C₂₁H₁₅NO₃
• Molecular Weight: 329.355
• Mol file: 1310066-81-9.mol

Synonyms:1-benzoylpyrrolo[1,2-a]quinoline-2-carboxylic acid methyl ester

Chemical Property of 1-benzoylpyrrolo[1,2-a]quinoline-2-carboxylic acid methyl ester

Chemical Property:

Purity/Quality:

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Technology Process of 1-benzoylpyrrolo[1,2-a]quinoline-2-carboxylic acid methyl ester

There total 4 articles about 1-benzoylpyrrolo[1,2-a]quinoline-2-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

1-phenacylquinolinium bromide (33014-32-3) + propynoic acid methyl ester (922-67-8) → 1-benzoylpyrrolo[1,2-a]quinoline-2-carboxylic acid methyl ester (1310066-81-9)

Guidance literature:

With triphenylphosphine; In N,N-dimethyl-formamide; at -5 - 20 ℃; for 12h; regioselective reaction;

DOI:10.1080/00397911.2015.1092550

Reference yield: 50.0%

1-phenacylquinolinium bromide (33014-32-3) + acrylic acid methyl ester (292638-85-8,9003-21-8,96-33-3) → 1-benzoylpyrrolo[1,2-a]quinoline-2-carboxylic acid methyl ester (1310066-81-9)

Guidance literature:

With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In chloroform; water; at 20 ℃;

DOI:10.1016/j.ejmech.2011.02.066

Reference yield:

α-bromoacetophenone (70-11-1) → 1-benzoylpyrrolo[1,2-a]quinoline-2-carboxylic acid methyl ester (1310066-81-9)

Guidance literature:

Multi-step reaction with 2 steps

1: diethyl ether / 20 °C

2: 2,3-dicyano-5,6-dichloro-p-benzoquinone / chloroform; water / 20 °C

With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In diethyl ether; chloroform; water;

DOI:10.1016/j.ejmech.2011.02.066

upstream raw materials:

quinoline

1-phenacylquinolinium bromide

acrylic acid methyl ester

α-bromoacetophenone