1-(2,5-dimethoxy-3,6-dimethoxymethyloxyphenyl)-16-(3,5-dimethoxymethyloxyphenyl)-8-Z-hexadecene

Base Information

Chemical Name:1-(2,5-dimethoxy-3,6-dimethoxymethyloxyphenyl)-16-(3,5-dimethoxymethyloxyphenyl)-8-Z-hexadecene
CAS No.:219630-89-4
Molecular Formula:C₃₈H₆₀O₁₀
Molecular Weight:676.888
Hs Code.:

Synonyms:1-(2,5-dimethoxy-3,6-dimethoxymethyloxyphenyl)-16-(3,5-dimethoxymethyloxyphenyl)-8-Z-hexadecene

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Chemical Property of 1-(2,5-dimethoxy-3,6-dimethoxymethyloxyphenyl)-16-(3,5-dimethoxymethyloxyphenyl)-8-Z-hexadecene

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Technology Process of 1-(2,5-dimethoxy-3,6-dimethoxymethyloxyphenyl)-16-(3,5-dimethoxymethyloxyphenyl)-8-Z-hexadecene

There total 14 articles about 1-(2,5-dimethoxy-3,6-dimethoxymethyloxyphenyl)-16-(3,5-dimethoxymethyloxyphenyl)-8-Z-hexadecene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 219630-88-3
1-(2,5-dimethoxy-3,6-dimethoxymethyloxyphenyl)-16-(3,5-dimethoxymethyloxyphenyl)hexadeca-8-yne

: 219630-89-4
1-(2,5-dimethoxy-3,6-dimethoxymethyloxyphenyl)-16-(3,5-dimethoxymethyloxyphenyl)-8-Z-hexadecene

Guidance literature:: With hydrogen; Pd-BaSO₄; In pyridine; for 36h;
DOI:10.1248/cpb.46.1770

Reference yield:

: 4549-31-9
1,7-dibromoheptane

: 219630-89-4
1-(2,5-dimethoxy-3,6-dimethoxymethyloxyphenyl)-16-(3,5-dimethoxymethyloxyphenyl)-8-Z-hexadecene

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) n-BuLi, TMEDA, 2.) HMPA / 1.) toluene, hexane, -78 deg C, 1 h, 2.) toluene, hexane, from -78 deg C to RT, 2.5 h

2: 1.) nBuLi, HMPA / 1.) THF, hexane, -78 deg C, 1 h, 2.) THF, hexane, from -78 deg C to RT, 4.5 h

3: 98 percent / TBAF / tetrahydrofuran / 1 h / Ambient temperature

4: 1.) LDA, 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone / 1.) THF, hexane, -78 deg C, 2 h, 2.) THF, hexane, from -78 deg C to RT, overnight

5: 85 percent / H₂ / Pd/BaSO₄ / pyridine / 36 h

With N,N,N,N,N,N-hexamethylphosphoric triamide; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; n-butyllithium; N,N,N,N,-tetramethylethylenediamine; tetrabutyl ammonium fluoride; hydrogen; lithium diisopropyl amide; Pd-BaSO₄; In tetrahydrofuran; pyridine;
DOI:10.1248/cpb.46.1770

Reference yield:

: 52483-31-5
1,3-dimethoxy-5-(7'-hydroxyheptyl)benzene

: 219630-89-4
1-(2,5-dimethoxy-3,6-dimethoxymethyloxyphenyl)-16-(3,5-dimethoxymethyloxyphenyl)-8-Z-hexadecene

Guidance literature:: Multi-step reaction with 6 steps

1: Et₃N / CH₂Cl₂ / 0.25 h / 0 °C

2: 100 percent / BBr₃ / CH₂Cl₂ / 2 h / -78 - 20 °C

3: 87 percent / N,N-diisopropylamine / CH₂Cl₂ / 48 h / Ambient temperature

4: 98 percent / NaI / acetone / 48 h / Heating

5: 1.) LDA, 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone / 1.) THF, hexane, -78 deg C, 2 h, 2.) THF, hexane, from -78 deg C to RT, overnight

6: 85 percent / H₂ / Pd/BaSO₄ / pyridine / 36 h

With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; hydrogen; boron tribromide; triethylamine; diisopropylamine; sodium iodide; lithium diisopropyl amide; Pd-BaSO₄; In pyridine; dichloromethane; acetone;
DOI:10.1248/cpb.46.1770