1-(2,5-dimethoxy-3,6-dimethoxymethyloxyphenyl)-16-(3,5-dimethoxymethyloxyphenyl)hexadeca-8-yne

Base Information

Chemical Name:1-(2,5-dimethoxy-3,6-dimethoxymethyloxyphenyl)-16-(3,5-dimethoxymethyloxyphenyl)hexadeca-8-yne
CAS No.:219630-88-3
Molecular Formula:C₃₈H₅₈O₁₀
Molecular Weight:674.873
Hs Code.:

Synonyms:1-(2,5-dimethoxy-3,6-dimethoxymethyloxyphenyl)-16-(3,5-dimethoxymethyloxyphenyl)hexadeca-8-yne

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Chemical Property of 1-(2,5-dimethoxy-3,6-dimethoxymethyloxyphenyl)-16-(3,5-dimethoxymethyloxyphenyl)hexadeca-8-yne

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Technology Process of 1-(2,5-dimethoxy-3,6-dimethoxymethyloxyphenyl)-16-(3,5-dimethoxymethyloxyphenyl)hexadeca-8-yne

There total 12 articles about 1-(2,5-dimethoxy-3,6-dimethoxymethyloxyphenyl)-16-(3,5-dimethoxymethyloxyphenyl)hexadeca-8-yne which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 101492-91-5
6-benzyloxy-1-hexanal

: 219630-88-3
1-(2,5-dimethoxy-3,6-dimethoxymethyloxyphenyl)-16-(3,5-dimethoxymethyloxyphenyl)hexadeca-8-yne

Guidance literature:: Multi-step reaction with 7 steps

1: 1.) n-BuLi / 1.) THF, hexane, RT, 15 min, 2.) THF, hexane, RT, 3 h

2: 85 percent / H₂ / 10 percent Pd/C / ethanol / 24 h / 760 Torr

3: Et₃N / CH₂Cl₂ / 0.25 h / 0 °C

4: 100 percent / BBr₃ / CH₂Cl₂ / 2 h / -78 - 20 °C

5: 87 percent / N,N-diisopropylamine / CH₂Cl₂ / 48 h / Ambient temperature

6: 98 percent / NaI / acetone / 48 h / Heating

7: 1.) LDA, 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone / 1.) THF, hexane, -78 deg C, 2 h, 2.) THF, hexane, from -78 deg C to RT, overnight

With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; n-butyllithium; hydrogen; boron tribromide; triethylamine; diisopropylamine; sodium iodide; lithium diisopropyl amide; palladium on activated charcoal; In ethanol; dichloromethane; acetone;
DOI:10.1248/cpb.46.1770

Reference yield:

: 24131-30-4
(3,5-dimethoxybenzyl)triphenylphosphonium bromide

: 219630-88-3
1-(2,5-dimethoxy-3,6-dimethoxymethyloxyphenyl)-16-(3,5-dimethoxymethyloxyphenyl)hexadeca-8-yne

Guidance literature:: Multi-step reaction with 7 steps

1: 1.) n-BuLi / 1.) THF, hexane, RT, 15 min, 2.) THF, hexane, RT, 3 h

2: 85 percent / H₂ / 10 percent Pd/C / ethanol / 24 h / 760 Torr

3: Et₃N / CH₂Cl₂ / 0.25 h / 0 °C

4: 100 percent / BBr₃ / CH₂Cl₂ / 2 h / -78 - 20 °C

5: 87 percent / N,N-diisopropylamine / CH₂Cl₂ / 48 h / Ambient temperature

6: 98 percent / NaI / acetone / 48 h / Heating

7: 1.) LDA, 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone / 1.) THF, hexane, -78 deg C, 2 h, 2.) THF, hexane, from -78 deg C to RT, overnight

With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; n-butyllithium; hydrogen; boron tribromide; triethylamine; diisopropylamine; sodium iodide; lithium diisopropyl amide; palladium on activated charcoal; In ethanol; dichloromethane; acetone;
DOI:10.1248/cpb.46.1770

Reference yield:

: 1,3-dimethoxy-5-(7'-benzyloxy-1-heptenyl)benzene

: 219630-88-3
1-(2,5-dimethoxy-3,6-dimethoxymethyloxyphenyl)-16-(3,5-dimethoxymethyloxyphenyl)hexadeca-8-yne

Guidance literature:: Multi-step reaction with 6 steps

1: 85 percent / H₂ / 10 percent Pd/C / ethanol / 24 h / 760 Torr

2: Et₃N / CH₂Cl₂ / 0.25 h / 0 °C

3: 100 percent / BBr₃ / CH₂Cl₂ / 2 h / -78 - 20 °C

4: 87 percent / N,N-diisopropylamine / CH₂Cl₂ / 48 h / Ambient temperature

5: 98 percent / NaI / acetone / 48 h / Heating

6: 1.) LDA, 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone / 1.) THF, hexane, -78 deg C, 2 h, 2.) THF, hexane, from -78 deg C to RT, overnight

With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; hydrogen; boron tribromide; triethylamine; diisopropylamine; sodium iodide; lithium diisopropyl amide; palladium on activated charcoal; In ethanol; dichloromethane; acetone;
DOI:10.1248/cpb.46.1770