3,4-dimethoxy-N-phenylbenzamide

Base Information

• Chemical Name: 3,4-dimethoxy-N-phenylbenzamide
• CAS No.: 1522-67-4
• Molecular Formula: C15H15 N O3
• Molecular Weight: 257.289
• Hs Code.: 2924299090
• DSSTox Substance ID: DTXSID40353143
• Nikkaji Number: J729.075F
• Wikidata: Q82130596
• ChEMBL ID: CHEMBL478705
• Mol file: 1522-67-4.mol

Synonyms:3,4-dimethoxy-N-phenylbenzamide;1522-67-4;3,4-Dimethoxybenzanilide;N-Phenyl-3,4-dimethoxybenzamide;Oprea1_114216;CHEMBL478705;SCHEMBL4141962;DTXSID40353143;3,4-dimethoxy-n-phenyl-benzamide;GKGPOEMZGIABNE-UHFFFAOYSA-N;CCG-42418;STK075069;AKOS001093158;CS-0302699;FT-0711037;SR-01000632419-1;Z27782784

Chemical Property of 3,4-dimethoxy-N-phenylbenzamide

Chemical Property:

• PSA: 47.56000
• LogP: 3.02910
• Storage Temp.: 2-8°C
• XLogP3: 2.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 257.10519334
• Heavy Atom Count: 19
• Complexity: 289

Purity/Quality:

98%min ^*data from raw suppliers

3,4-Dimethoxybenzanilide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(C=C(C=C1)C(=O)NC2=CC=CC=C2)OC

Technology Process of 3,4-dimethoxy-N-phenylbenzamide

There total 18 articles about 3,4-dimethoxy-N-phenylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

Veratric acid (93-07-2) + aniline (62-53-3) → N-phenyl-3,4-dimethoxybenzamide (1522-67-4)

Guidance literature:

With diphosphorus tetraiodide; In tetrachloromethane; dichloromethane; Heating;

DOI:10.1246/cl.1983.449

Reference yield: 93.0%

1,2-dimethoxybenzene (91-16-7) + phenyl isocyanate (103-71-9) → N-phenyl-3,4-dimethoxybenzamide (1522-67-4)

Guidance literature:

With methanesulfonic acid; In neat (no solvent); at 20 ℃; Cooling with ice;

DOI:10.1039/c4ra12944j

Reference yield: 83.0%

aniline (62-53-3) + 3,4-dimethoxybenzoic acid chloride (3535-37-3) → N-phenyl-3,4-dimethoxybenzamide (1522-67-4)

Guidance literature:

With 1,6-anhydro-3,4-dideoxy-β-D-glycero-hexopyranos-2-ulose; triethylamine; at 0 - 20 ℃; for 1h;

DOI:10.1039/c9gc01180c

upstream raw materials:

diazomethane

3,4-dihydroxy-benzoic acid anilide

aniline

3,4-dimethoxybenzoic acid chloride

Downstream raw materials:

4,5-dimethoxyisobenzofuran-1(3H)-one

N-phenyl-3,4-dimethoxy-2-(4'-methoxybenzyl)benzamide

4,5-dimethoxy-3-(4'-methoxyphenyl)phthalide

3,4-dimethoxy-2-(4'-methoxybenzyl)benzoic acid

Refernces

• 1、 Sintov et al.. "-". . p. 3990. Retrieved 1949.
• 2、 Beauchemin, André M.,Derasp, Joshua S.. "Rhodium-Catalyzed Synthesis of Amides from Functionalized Blocked Isocyanates". . p. 8104 - 8109. Retrieved 2019/08/26.
• 3、 Varun, Begur Vasanthkumar,Sood, Ankush,Prabhu, Kandikere Ramaiah. "A metal-free and a solvent-free synthesis of thio-amides and amides: An efficient Friedel-Crafts arylation of isothiocyanates and isocyanates". . p. 60798 - 60807. Retrieved 2015/02/19.