2-Methyl-6-phenylpyrazine

Base Information

• Chemical Name: 2-Methyl-6-phenylpyrazine
• CAS No.: 74233-03-7
• Molecular Formula: C₁₁H₁₀N₂
• Molecular Weight: 170.214
• UNII: Y8FFZ6SOM7
• Nikkaji Number: J855.276B
• Mol file: 74233-03-7.mol

Synonyms:2-Methyl-6-phenylpyrazine;74233-03-7;Y8FFZ6SOM7;2-Methyl-6-phenyl-pyrazine;Pyrazine, 2-methyl-6-phenyl-;UNII-Y8FFZ6SOM7;SCHEMBL2614938;EN300-8308869

Chemical Property of 2-Methyl-6-phenylpyrazine

Chemical Property:

• Storage Temp.: 2-8°C
• XLogP3: 1.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 170.084398327
• Heavy Atom Count: 13
• Complexity: 152

Purity/Quality:

95+% ^*data from raw suppliers

2-Methyl-6-phenylpyrazine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC1=CN=CC(=N1)C2=CC=CC=C2

Technology Process of 2-Methyl-6-phenylpyrazine

There total 10 articles about 2-Methyl-6-phenylpyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

2-chloro-6-methylpyrazine (38557-71-0) + phenylboronic acid (98-80-6) → 6-methyl-2-phenylpyrazine (74233-03-7)

Guidance literature:

2-chloro-6-methylpyrazine; phenylboronic acid; With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In water; toluene; at 95 ℃; for 0.166667h; Inert atmosphere;

With potassium fluoride dihydrate; In water; toluene; at 95 ℃; Inert atmosphere;

DOI:10.1021/acs.orglett.6b01190

Reference yield: 74.0%

2-chloro-3-methyl-5-phenylpyrazine (81225-11-8) → 6-methyl-2-phenylpyrazine (74233-03-7)

Guidance literature:

With hydrogen; sodium acetate; palladium on activated charcoal; In ethanol;

Reference yield: 45.0%

tert-butyl 2-(hydroxyimino)-2-phenylethyl(prop-2-ynyl)carbamate (1201003-60-2) → 6-methyl-2-phenylpyrazine (74233-03-7)

Guidance literature:

tert-butyl 2-(hydroxyimino)-2-phenylethyl(prop-2-ynyl)carbamate; With toluene-4-sulfonic acid; In chlorobenzene; at 180 ℃; for 8h; Microwave irradiation; Inert atmosphere;

With triethylamine; In chlorobenzene;

DOI:10.1002/anie.200903922

upstream raw materials:

2-chloro-3-methyl-5-phenylpyrazine

methyllithium

2-phenylpyrazine

phenyllithium

Downstream raw materials:

2-methyl-6-phenylpyrazine 4-oxide

3-hydroxy-2-methyl-6-phenylpyrazine

2-hydroxymethyl-6-phenylpyrazine

2-methyl-6-phenylpyrazine 1-oxide