(E)-3-[(2S,3R)-2,3-dihydro-3-hydroxymethyl-7-methoxy-2-(3',4'-dimethoxyphenyl)-1-benzo[b]furan-5-yl]-2-propenal

Base Information

Chemical Name:(E)-3-[(2S,3R)-2,3-dihydro-3-hydroxymethyl-7-methoxy-2-(3',4'-dimethoxyphenyl)-1-benzo[b]furan-5-yl]-2-propenal
CAS No.:215228-10-7
Molecular Formula:C₂₁H₂₂O₆
Molecular Weight:370.402
Hs Code.:

Synonyms:(E)-3-[(2S,3R)-2,3-dihydro-3-hydroxymethyl-7-methoxy-2-(3',4'-dimethoxyphenyl)-1-benzo[b]furan-5-yl]-2-propenal

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Chemical Property of (E)-3-[(2S,3R)-2,3-dihydro-3-hydroxymethyl-7-methoxy-2-(3',4'-dimethoxyphenyl)-1-benzo[b]furan-5-yl]-2-propenal

Chemical Property:

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MSDS Files:: SDS file from LookChem

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Technology Process of (E)-3-[(2S,3R)-2,3-dihydro-3-hydroxymethyl-7-methoxy-2-(3',4'-dimethoxyphenyl)-1-benzo[b]furan-5-yl]-2-propenal

There total 5 articles about (E)-3-[(2S,3R)-2,3-dihydro-3-hydroxymethyl-7-methoxy-2-(3',4'-dimethoxyphenyl)-1-benzo[b]furan-5-yl]-2-propenal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 215319-47-4
(E)-3-[(2S,3R)-2,3-dihydro-2-(4'-hydroxy-3'-methoxyphenyl)-3-hydroxymethyl-7-methoxy-1-benzo[b]furan-5-yl]-2-propenal

: 74-88-4
methyl iodide

: 215228-10-7
(E)-3-[(2S,3R)-2,3-dihydro-3-hydroxymethyl-7-methoxy-2-(3',4'-dimethoxyphenyl)-1-benzo[b]furan-5-yl]-2-propenal

Guidance literature:: With potassium carbonate; In acetone; for 1h;
DOI:10.1016/S0040-4020(98)00725-X

Reference yield:

: 118799-85-2
(E)-3-[(2R*,3S*)-2,3-dihydro-3-hydroxymethyl-7-methoxy-2-(3-methoxy-4-methoxymethoxyphenyl)-1-benzofuran-5-yl]-2-propenal

: 215228-10-7
(E)-3-[(2S,3R)-2,3-dihydro-3-hydroxymethyl-7-methoxy-2-(3',4'-dimethoxyphenyl)-1-benzo[b]furan-5-yl]-2-propenal

Guidance literature:: Multi-step reaction with 4 steps

1: 5 mg / DIPEA / CH₂Cl₂ / 3 h / Ambient temperature

2: 88 percent / K₂CO₃ / methanol; tetrahydrofuran / 0.5 h

3: 90 percent / aq. HCl / methanol / 3 h

4: 89 percent / K₂CO₃ / acetone / 1 h

With hydrogenchloride; potassium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dichloromethane; acetone;
DOI:10.1016/S0040-4020(98)00725-X

Reference yield:

: 215227-86-4
(1S,4R)-4,7,7-Trimethyl-3-oxo-2-oxa-bicyclo[2.2.1]heptane-1-carboxylic acid (2S,3R)-7-methoxy-2-(3-methoxy-4-methoxymethoxy-phenyl)-5-((E)-3-oxo-propenyl)-2,3-dihydro-benzofuran-3-ylmethyl ester

: 215228-10-7
(E)-3-[(2S,3R)-2,3-dihydro-3-hydroxymethyl-7-methoxy-2-(3',4'-dimethoxyphenyl)-1-benzo[b]furan-5-yl]-2-propenal

Guidance literature:: Multi-step reaction with 3 steps

1: 88 percent / K₂CO₃ / methanol; tetrahydrofuran / 0.5 h

2: 90 percent / aq. HCl / methanol / 3 h

3: 89 percent / K₂CO₃ / acetone / 1 h

With hydrogenchloride; potassium carbonate; In tetrahydrofuran; methanol; acetone;
DOI:10.1016/S0040-4020(98)00725-X