2-({[(9H-Fluoren-9-yl)methoxy](hydroxy)methylidene}amino)-3-(pyridin-3-yl)propanoate

Base Information

Chemical Name:2-({[(9H-Fluoren-9-yl)methoxy](hydroxy)methylidene}amino)-3-(pyridin-3-yl)propanoate
CAS No.:142994-45-4
Molecular Formula:C₂₃H₂₀N₂O₄
Molecular Weight:388.423
Hs Code.:29333990
DSSTox Substance ID:DTXSID10931710
Wikidata:Q72478853
Mol file:142994-45-4.mol

Synonyms:DTXSID10931710;2-({[(9H-Fluoren-9-yl)methoxy](hydroxy)methylidene}amino)-3-(pyridin-3-yl)propanoate

Suppliers and Price of 2-({[(9H-Fluoren-9-yl)methoxy](hydroxy)methylidene}amino)-3-(pyridin-3-yl)propanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Fmoc-d-3-pyridylalanine
100mg
$ 55.00

TRC
Fmoc-d-3-pyridylalanine
1g
$ 250.00

SynQuest Laboratories
3-Pyridin-3-yl-D-alanine, N-Fmoc protected
5 g
$ 344.00

SynQuest Laboratories
3-Pyridin-3-yl-D-alanine, N-Fmoc protected
10 g
$ 544.00

SynQuest Laboratories
3-Pyridin-3-yl-D-alanine, N-Fmoc protected
1 g
$ 168.00

Sigma-Aldrich
Fmoc-β-(3-pyridyl)-D-Ala-OH purum, ≥98.0% (HPLC)
1g
$ 219.00

Matrix Scientific
Fmoc-D-3-pyridylalanine
1g
$ 155.00

Matrix Scientific
Fmoc-D-3-pyridylalanine
5g
$ 555.00

Iris Biotech GmbH
Fmoc-D-3Pal-OH
5 g
$ 877.50

Crysdot
Fmoc-D-3-Pal-OH 95+%
10g
$ 267.00

Total 77 raw suppliers

Chemical Property of 2-({[(9H-Fluoren-9-yl)methoxy](hydroxy)methylidene}amino)-3-(pyridin-3-yl)propanoate

Chemical Property:

Appearance/Colour:white crystalline powder
Vapor Pressure:1.5E-17mmHg at 25°C
Melting Point:166.5 °C
Refractive Index:1.6300 (estimate)
Boiling Point:645.6 °C at 760 mmHg
PKA:3.32±0.10(Predicted)
Flash Point:344.3 °C
PSA：88.52000
Density:1.309 g/cm³
LogP:4.00690
Storage Temp.:2-8°C
Solubility.:Dichloromethane (Sparingly), DMSO (Slightly), Methanol (Slightly, Sonicated)
XLogP3:4.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:6
Exact Mass:387.13448209
Heavy Atom Count:29
Complexity:556

Purity/Quality:

≥98%,≥99%, ^*data from raw suppliers

Fmoc-d-3-pyridylalanine ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi
Hazard Codes:Xi
Safety Statements: 22-24/25

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C2C(=C1)C(C3=CC=CC=C32)COC(=O)NC(CC4=CN=CC=C4)C(=O)[O-]
Isomeric SMILES:C1=CC=C2C(=C1)C(C3=CC=CC=C32)COC(=O)N[C@H](CC4=CN=CC=C4)C(=O)[O-]
Uses Fmoc-d-3-pyridylalanine, is an amino acid building block used in peptide synthesis. With a growing peptide drug market the fast, reliable synthesis of peptides is of great importance.

Technology Process of 2-({[(9H-Fluoren-9-yl)methoxy](hydroxy)methylidene}amino)-3-(pyridin-3-yl)propanoate

There total 12 articles about 2-({[(9H-Fluoren-9-yl)methoxy](hydroxy)methylidene}amino)-3-(pyridin-3-yl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 1397697-66-3
N-fluorenylmethyloxycarbonyl-3-pyridylalanine-methyl ester

: 1397697-68-5
C₂₄H₂₂N₂O₄

: 175453-07-3,142994-45-4
(S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(pyridin-3-yl)propanoic acid

Guidance literature:: With ammonium hydroxide; α-chymotrypsine; ammonium acetate; In water; N,N-dimethyl-formamide; at 20 ℃; for 2h; pH=6.9; optical yield given as %ee; Enzymatic reaction;
DOI:10.1007/s00726-010-0829-3

Reference yield:

: 17470-24-5,28105-69-3,64090-98-8,70702-47-5
2-amino-3-(pyridin-3-yl)propanoic acid

: 82911-69-1
N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide

: 746672-88-8,175453-07-3,142994-45-4
C₂₃H₂₀N₂O₄

Guidance literature:: With sodium hydrogencarbonate; In 1,4-dioxane; water; at 20 ℃; for 22h;
DOI:10.1007/s00726-010-0829-3

Reference yield:

: 17470-24-5,28105-69-3,64090-98-8,70702-47-5
2-amino-3-(pyridin-3-yl)propanoic acid

: 1397697-68-5
C₂₄H₂₂N₂O₄

: 175453-07-3,142994-45-4
(S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(pyridin-3-yl)propanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydrogencarbonate / 1,4-dioxane; water / 22 h / 20 °C

2: chloro-trimethyl-silane / 36 h / 40 °C

3: ammonium hydroxide; α-chymotrypsine; ammonium acetate / water; N,N-dimethyl-formamide / 2 h / 20 °C / pH 6.9 / Enzymatic reaction

With ammonium hydroxide; chloro-trimethyl-silane; α-chymotrypsine; ammonium acetate; sodium hydrogencarbonate; In 1,4-dioxane; water; N,N-dimethyl-formamide;
DOI:10.1007/s00726-010-0829-3