7-(7-(benzyloxy)benzo[d][1,3]dioxol-5-yl)-1-(4-bromophenyl)-5-hydroxyheptan-3-one

Base Information

Chemical Name:7-(7-(benzyloxy)benzo[d][1,3]dioxol-5-yl)-1-(4-bromophenyl)-5-hydroxyheptan-3-one
CAS No.:1426838-69-8
Molecular Formula:C₂₇H₂₇BrO₅
Molecular Weight:511.412
Hs Code.:

Synonyms:7-(7-(benzyloxy)benzo[d][1,3]dioxol-5-yl)-1-(4-bromophenyl)-5-hydroxyheptan-3-one

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Chemical Property of 7-(7-(benzyloxy)benzo[d][1,3]dioxol-5-yl)-1-(4-bromophenyl)-5-hydroxyheptan-3-one

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Technology Process of 7-(7-(benzyloxy)benzo[d][1,3]dioxol-5-yl)-1-(4-bromophenyl)-5-hydroxyheptan-3-one

There total 4 articles about 7-(7-(benzyloxy)benzo[d][1,3]dioxol-5-yl)-1-(4-bromophenyl)-5-hydroxyheptan-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 1426838-68-7
3-(7-(benzyloxy)benzo[d][1,3]dioxol-5-yl)propanal

: 89201-84-3
4-(4-bromophenyl)-2-butanone

: 1426838-69-8
7-(7-(benzyloxy)benzo[d][1,3]dioxol-5-yl)-1-(4-bromophenyl)-5-hydroxyheptan-3-one

Guidance literature:: 4-(4-bromophenyl)-2-butanone; With n-butyllithium; diisopropylamine; In tetrahydrofuran; hexane; at -78 ℃; for 1h; Inert atmosphere;

3-(7-(benzyloxy)benzo[d][1,3]dioxol-5-yl)propanal; In tetrahydrofuran; hexane; at -78 ℃; for 2.5h; Inert atmosphere;
DOI:10.1021/jo400157d

Reference yield:

: 221177-68-0
7-(benzyloxy)benzo[d][1,3]dioxole-5-carbaldehyde

: 1426838-69-8
7-(7-(benzyloxy)benzo[d][1,3]dioxol-5-yl)-1-(4-bromophenyl)-5-hydroxyheptan-3-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / tetrahydrofuran / 0.67 h / 0 °C / Inert atmosphere

1.2: 0 - 20 °C / Inert atmosphere

2.1: sodium acetate; toluene-4-sulfonic acid hydrazide / tetrahydrofuran; water / 24 h / 80 °C / Inert atmosphere

3.1: diisobutylaluminium hydride / dichloromethane; toluene / 0.25 h / -78 °C / Inert atmosphere

4.1: diisopropylamine; n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere

4.2: 2.5 h / -78 °C / Inert atmosphere

With n-butyllithium; sodium acetate; sodium hydride; diisobutylaluminium hydride; diisopropylamine; toluene-4-sulfonic acid hydrazide; In tetrahydrofuran; hexane; dichloromethane; water; toluene;
DOI:10.1021/jo400157d

Reference yield:

: 1426838-66-5
(E)-ethyl 3-(7-(benzyloxy)benzo[d][1,3]dioxol-5-yl)acrylate

: 1426838-69-8
7-(7-(benzyloxy)benzo[d][1,3]dioxol-5-yl)-1-(4-bromophenyl)-5-hydroxyheptan-3-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium acetate; toluene-4-sulfonic acid hydrazide / tetrahydrofuran; water / 24 h / 80 °C / Inert atmosphere

2.1: diisobutylaluminium hydride / dichloromethane; toluene / 0.25 h / -78 °C / Inert atmosphere

3.1: diisopropylamine; n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere

3.2: 2.5 h / -78 °C / Inert atmosphere

With n-butyllithium; sodium acetate; diisobutylaluminium hydride; diisopropylamine; toluene-4-sulfonic acid hydrazide; In tetrahydrofuran; hexane; dichloromethane; water; toluene;
DOI:10.1021/jo400157d