methyl 3β-[bis(butoxycarbonyl)methyl]-3α-[(p-tert-butoxymethyl)phenyl]-7α,12α-bis(formyloxy)-24-nor-5β-cholan-23-oate

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Chemical Name:methyl 3β-[bis(butoxycarbonyl)methyl]-3α-[(p-tert-butoxymethyl)phenyl]-7α,12α-bis(formyloxy)-24-nor-5β-cholan-23-oate
CAS No.:198016-16-9
Molecular Formula:C₄₈H₇₂O₁₁
Molecular Weight:825.093
Hs Code.:

Synonyms:methyl 3β-[bis(butoxycarbonyl)methyl]-3α-[(p-tert-butoxymethyl)phenyl]-7α,12α-bis(formyloxy)-24-nor-5β-cholan-23-oate

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Chemical Property of methyl 3β-[bis(butoxycarbonyl)methyl]-3α-[(p-tert-butoxymethyl)phenyl]-7α,12α-bis(formyloxy)-24-nor-5β-cholan-23-oate

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Technology Process of methyl 3β-[bis(butoxycarbonyl)methyl]-3α-[(p-tert-butoxymethyl)phenyl]-7α,12α-bis(formyloxy)-24-nor-5β-cholan-23-oate

There total 6 articles about methyl 3β-[bis(butoxycarbonyl)methyl]-3α-[(p-tert-butoxymethyl)phenyl]-7α,12α-bis(formyloxy)-24-nor-5β-cholan-23-oate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 22807-80-3
1-bromo-4-(tert-butoxymethyl)benzene

: 198016-15-8
methyl 3-[bis(butoxycarbonyl)methylidene]-7α,12α-bis(formyloxy)-24-nor-5β-cholan-23-oate

: 198016-16-9
methyl 3β-[bis(butoxycarbonyl)methyl]-3α-[(p-tert-butoxymethyl)phenyl]-7α,12α-bis(formyloxy)-24-nor-5β-cholan-23-oate

Guidance literature:: 1-bromo-4-(tert-butoxymethyl)benzene; With magnesium; In tetrahydrofuran; for 1h; sonication;

In tetrahydrofuran; at -10 - 0 ℃;

methyl 3-[bis(butoxycarbonyl)methylidene]-7α,12α-bis(formyloxy)-24-nor-5β-cholan-23-oate; In tetrahydrofuran; at -60 - 20 ℃;
DOI:10.1021/jo971272w

Reference yield:

: 60696-62-0
24-norcholic acid

: 198016-16-9
methyl 3β-[bis(butoxycarbonyl)methyl]-3α-[(p-tert-butoxymethyl)phenyl]-7α,12α-bis(formyloxy)-24-nor-5β-cholan-23-oate

Guidance literature:: Multi-step reaction with 6 steps

1.1: 90 percent / HClO₄; Ac₂O

2.1: CH₂Cl₂; methanol / -5 - 0 °C

3.1: 13.84 g / sodium bicarbonate / methanol / 1.8 h / 0 °C

4.1: 86 percent / silica gel; pyridinium chlorochromate / CH₂Cl₂ / 2 h

5.1: 96 percent / SbBu₃ / tetrahydrofuran / 74 h / 60 - 65 °C

6.1: magnesium / tetrahydrofuran / 1 h / sonication

6.2: CuCN / tetrahydrofuran / -10 - 0 °C

6.3: 91 percent / tetrahydrofuran / -60 - 20 °C

With perchloric acid; acetic anhydride; silica gel; tributylstibine; sodium hydrogencarbonate; magnesium; pyridinium chlorochromate; In tetrahydrofuran; methanol; dichloromethane; 1.1: Esterification / 2.1: Methylation / 3.1: deformylation / 4.1: Oxidation / 5.1: Condensation / 6.1: Metallation / 6.2: transmetallation / 6.3: Addition;
DOI:10.1021/jo971272w

Reference yield:

: 68777-19-5
24-norcholic acid triformate

: 198016-16-9
methyl 3β-[bis(butoxycarbonyl)methyl]-3α-[(p-tert-butoxymethyl)phenyl]-7α,12α-bis(formyloxy)-24-nor-5β-cholan-23-oate

Guidance literature:: Multi-step reaction with 5 steps

1.1: CH₂Cl₂; methanol / -5 - 0 °C

2.1: 13.84 g / sodium bicarbonate / methanol / 1.8 h / 0 °C

3.1: 86 percent / silica gel; pyridinium chlorochromate / CH₂Cl₂ / 2 h

4.1: 96 percent / SbBu₃ / tetrahydrofuran / 74 h / 60 - 65 °C

5.1: magnesium / tetrahydrofuran / 1 h / sonication

5.2: CuCN / tetrahydrofuran / -10 - 0 °C

5.3: 91 percent / tetrahydrofuran / -60 - 20 °C

With silica gel; tributylstibine; sodium hydrogencarbonate; magnesium; pyridinium chlorochromate; In tetrahydrofuran; methanol; dichloromethane; 1.1: Methylation / 2.1: deformylation / 3.1: Oxidation / 4.1: Condensation / 5.1: Metallation / 5.2: transmetallation / 5.3: Addition;
DOI:10.1021/jo971272w