(1R,2R)-2-AMINO-CYCLOHEXANECARBOXYLIC ACID ETHYL ESTER

Base Information

• Chemical Name: (1R,2R)-2-AMINO-CYCLOHEXANECARBOXYLIC ACID ETHYL ESTER
• CAS No.: 1436-60-8
• Molecular Formula: C₉H₁₇NO₂
• Molecular Weight: 171.239
• Mol file: 1436-60-8.mol

Synonyms:Cyclohexanecarboxylicacid, 2-amino-, ethyl ester, cis- (8CI); Ethyl cis-2-amino-1-cyclohexanecarboxylate;Ethyl cis-2-amino-1-cyclohexanecarboxylate; Ethylcis-2-aminocyclohexanecarboxylate

Chemical Property of (1R,2R)-2-AMINO-CYCLOHEXANECARBOXYLIC ACID ETHYL ESTER

Chemical Property:

• Vapor Pressure: 0.0505mmHg at 25°C
• Melting Point: 233-234 °C
• Refractive Index: 1.468
• Boiling Point: 235.3°C at 760 mmHg
• PKA: 9.30±0.70(Predicted)
• Flash Point: 101.5°C
• PSA: 52.32000
• Density: 1.018g/cm³
• LogP: 1.76730
• Storage Temp.: Keep in dark place,Sealed in dry,Store in freezer, under -20°C

Purity/Quality:

98%min ^*data from raw suppliers

(1R,2R)-2-AMINO-CYCLOHEXANECARBOXYLIC ACID ETHYL ESTER 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (1R,2R)-2-AMINO-CYCLOHEXANECARBOXYLIC ACID ETHYL ESTER

There total 5 articles about (1R,2R)-2-AMINO-CYCLOHEXANECARBOXYLIC ACID ETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-carbamoylcyclohex-3-enecarboxylic acid (1469-49-4,2028-12-8) → ethyl cis-2-amino-1-cyclohexanecarboxylate (1436-60-8,1436-61-9,24716-94-7,26849-62-7,64162-07-8,75197-07-8,115014-75-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 91 percent / H₂ / 10percent Pt/C / ethanol / 760 Torr / Ambient temperature

2: 1.) bromine, NaOH; 2.) HCl / 1.) water, 75 deg C, 2 min; 2.) reflux, 3 h

With hydrogenchloride; sodium hydroxide; hydrogen; bromine; platinum on activated charcoal; In ethanol;

DOI:10.1016/S0040-4020(01)85926-3

Reference yield:

ethyl 2-aminocyclohex-1-ene-1-carboxylate (1128-00-3) → ethyl cis-2-amino-1-cyclohexanecarboxylate (1436-60-8,1436-61-9,24716-94-7,26849-62-7,64162-07-8,75197-07-8,115014-75-0)

Guidance literature:

With sodium cyanoborohydride; acetic acid; In ethyl acetate; at 0 ℃; for 6h;

DOI:10.1002/adsc.201300982

Reference yield:

ethyl 2-oxocyclohexane carboxylate (1655-07-8) → ethyl cis-2-amino-1-cyclohexanecarboxylate (1436-60-8,1436-61-9,24716-94-7,26849-62-7,64162-07-8,75197-07-8,115014-75-0)

Guidance literature:

Multi-step reaction with 2 steps

1: ammonium acetate / methanol / 48 h / 20 °C

2: sodium cyanoborohydride; acetic acid / ethyl acetate / 6 h / 0 °C

With ammonium acetate; sodium cyanoborohydride; acetic acid; In methanol; ethyl acetate;

DOI:10.1002/adsc.201300982

upstream raw materials:

ethyl 2-aminocyclohex-1-ene-1-carboxylate

ethanol

cis-1-carboxy-2-(aminocarboxyl)-2-cyclohexane

6-carbamoylcyclohex-3-enecarboxylic acid

Downstream raw materials:

(1RS,2SR)-2-aminocyclohexanecarboxylic acid

(+/-)-cis-2-(2-ethoxycarbonyl-ethylamino)-cyclohexane-carboxylic acid-⁽¹⁾-ethyl ester

cis-2-aminocyclohexane-1-carboxamide

trans-2-aminocyclohexane-1-carboxamide