Toluene-4-sulfonic acid (1S,4R,7aS)-4,7a-dimethyl-4-phenylsulfanylmethyl-2,4,5,6,7,7a-hexahydro-1H-inden-1-yl ester

Base Information

Chemical Name:Toluene-4-sulfonic acid (1S,4R,7aS)-4,7a-dimethyl-4-phenylsulfanylmethyl-2,4,5,6,7,7a-hexahydro-1H-inden-1-yl ester
CAS No.:194931-07-2
Molecular Formula:C₂₅H₃₀O₃S₂
Molecular Weight:442.643
Hs Code.:

Synonyms:Toluene-4-sulfonic acid (1S,4R,7aS)-4,7a-dimethyl-4-phenylsulfanylmethyl-2,4,5,6,7,7a-hexahydro-1H-inden-1-yl ester

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Chemical Property of Toluene-4-sulfonic acid (1S,4R,7aS)-4,7a-dimethyl-4-phenylsulfanylmethyl-2,4,5,6,7,7a-hexahydro-1H-inden-1-yl ester

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Technology Process of Toluene-4-sulfonic acid (1S,4R,7aS)-4,7a-dimethyl-4-phenylsulfanylmethyl-2,4,5,6,7,7a-hexahydro-1H-inden-1-yl ester

There total 4 articles about Toluene-4-sulfonic acid (1S,4R,7aS)-4,7a-dimethyl-4-phenylsulfanylmethyl-2,4,5,6,7,7a-hexahydro-1H-inden-1-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 98-59-9
p-toluenesulfonyl chloride

: 194931-06-1
(1S,4R,7aS)-4,7a-Dimethyl-4-phenylsulfanylmethyl-2,4,5,6,7,7a-hexahydro-1H-inden-1-ol

: 194931-07-2
Toluene-4-sulfonic acid (1S,4R,7aS)-4,7a-dimethyl-4-phenylsulfanylmethyl-2,4,5,6,7,7a-hexahydro-1H-inden-1-yl ester

Guidance literature:: With dmap; In dichloromethane; for 16h; Ambient temperature;
DOI:10.1039/a703164e

Reference yield:

: 51849-22-0
iodomethyl phenyl sulfide

: 194931-07-2
Toluene-4-sulfonic acid (1S,4R,7aS)-4,7a-dimethyl-4-phenylsulfanylmethyl-2,4,5,6,7,7a-hexahydro-1H-inden-1-yl ester

Guidance literature:: Multi-step reaction with 4 steps

1: KOBu-t / tetrahydrofuran / 1.) 0 deg C, 45 min, 2.) -78 deg C

2: 100 percent / HCl, H₂O / ethanol / 2 h / 25 °C

3: 87 percent / N₂H₄, H₂O, KOH / bis-(2-hydroxy-ethyl) ether / 1.) 100 deg C, 1 h, 2.) 200 deg C, 4 h

4: 99 percent / DMAP / CH₂Cl₂ / 16 h / 25 °C

With hydrogenchloride; dmap; potassium hydroxide; potassium tert-butylate; water; hydrazine; In tetrahydrofuran; ethanol; dichloromethane; diethylene glycol;
DOI:10.1002/(SICI)1521-3765(19980807)4:8<1480::AID-CHEM1480>3.0.CO;2-6

Reference yield:

: (1S,7aS)-4,7a-Dimethyl-1-(tetrahydro-pyran-2-yloxy)-1,2,3,6,7,7a-hexahydro-inden-5-one

: 194931-07-2
Toluene-4-sulfonic acid (1S,4R,7aS)-4,7a-dimethyl-4-phenylsulfanylmethyl-2,4,5,6,7,7a-hexahydro-1H-inden-1-yl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 81 percent / KOBu-t / tetrahydrofuran / 1.) 0 deg C, 2.) -78 deg C, 30 min

2: 100 percent / HCl / ethanol / 16 h / Ambient temperature

3: 87 percent / N₂H₄, KOH / bis-(2-hydroxy-ethyl) ether / 4 h / 200 °C

4: 99 percent / DMAP / CH₂Cl₂ / 16 h / Ambient temperature

With hydrogenchloride; dmap; potassium hydroxide; potassium tert-butylate; hydrazine; In tetrahydrofuran; ethanol; dichloromethane; diethylene glycol;
DOI:10.1039/a703164e