(1S,4R,7aS)-4,7a-Dimethyl-4-phenylsulfanylmethyl-2,4,5,6,7,7a-hexahydro-1H-inden-1-ol

Base Information

Chemical Name:(1S,4R,7aS)-4,7a-Dimethyl-4-phenylsulfanylmethyl-2,4,5,6,7,7a-hexahydro-1H-inden-1-ol
CAS No.:194931-06-1
Molecular Formula:C₁₈H₂₄OS
Molecular Weight:288.454
Hs Code.:

Synonyms:(1S,4R,7aS)-4,7a-Dimethyl-4-phenylsulfanylmethyl-2,4,5,6,7,7a-hexahydro-1H-inden-1-ol

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Chemical Property of (1S,4R,7aS)-4,7a-Dimethyl-4-phenylsulfanylmethyl-2,4,5,6,7,7a-hexahydro-1H-inden-1-ol

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Technology Process of (1S,4R,7aS)-4,7a-Dimethyl-4-phenylsulfanylmethyl-2,4,5,6,7,7a-hexahydro-1H-inden-1-ol

There total 4 articles about (1S,4R,7aS)-4,7a-Dimethyl-4-phenylsulfanylmethyl-2,4,5,6,7,7a-hexahydro-1H-inden-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 194931-05-0
(1S,4S,7aS)-1-Hydroxy-4,7a-dimethyl-4-phenylsulfanylmethyl-1,2,4,6,7,7a-hexahydro-inden-5-one

: 194931-06-1
(1S,4R,7aS)-4,7a-Dimethyl-4-phenylsulfanylmethyl-2,4,5,6,7,7a-hexahydro-1H-inden-1-ol

Guidance literature:: With potassium hydroxide; hydrazine; In diethylene glycol; at 200 ℃; for 4h;
DOI:10.1039/a703164e

Reference yield:

: 51849-22-0
iodomethyl phenyl sulfide

: 194931-06-1
(1S,4R,7aS)-4,7a-Dimethyl-4-phenylsulfanylmethyl-2,4,5,6,7,7a-hexahydro-1H-inden-1-ol

Guidance literature:: Multi-step reaction with 3 steps

1: KOBu-t / tetrahydrofuran / 1.) 0 deg C, 45 min, 2.) -78 deg C

2: 100 percent / HCl, H₂O / ethanol / 2 h / 25 °C

3: 87 percent / N₂H₄, H₂O, KOH / bis-(2-hydroxy-ethyl) ether / 1.) 100 deg C, 1 h, 2.) 200 deg C, 4 h

With hydrogenchloride; potassium hydroxide; potassium tert-butylate; water; hydrazine; In tetrahydrofuran; ethanol; diethylene glycol;
DOI:10.1002/(SICI)1521-3765(19980807)4:8<1480::AID-CHEM1480>3.0.CO;2-6

Reference yield:

: (1S,7aS)-4,7a-Dimethyl-1-(tetrahydro-pyran-2-yloxy)-1,2,3,6,7,7a-hexahydro-inden-5-one

: 194931-06-1
(1S,4R,7aS)-4,7a-Dimethyl-4-phenylsulfanylmethyl-2,4,5,6,7,7a-hexahydro-1H-inden-1-ol

Guidance literature:: Multi-step reaction with 3 steps

1: 81 percent / KOBu-t / tetrahydrofuran / 1.) 0 deg C, 2.) -78 deg C, 30 min

2: 100 percent / HCl / ethanol / 16 h / Ambient temperature

3: 87 percent / N₂H₄, KOH / bis-(2-hydroxy-ethyl) ether / 4 h / 200 °C

With hydrogenchloride; potassium hydroxide; potassium tert-butylate; hydrazine; In tetrahydrofuran; ethanol; diethylene glycol;
DOI:10.1039/a703164e