(E)-4-ethyl 1-methyl 2-(4-methoxyphenyl)fumarate

Base Information

Chemical Name:(E)-4-ethyl 1-methyl 2-(4-methoxyphenyl)fumarate
CAS No.:1285704-80-4
Molecular Formula:C₁₄H₁₆O₅
Molecular Weight:264.278
Hs Code.:

Synonyms:(E)-4-ethyl 1-methyl 2-(4-methoxyphenyl)fumarate

Suppliers and Price of (E)-4-ethyl 1-methyl 2-(4-methoxyphenyl)fumarate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (E)-4-ethyl 1-methyl 2-(4-methoxyphenyl)fumarate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (E)-4-ethyl 1-methyl 2-(4-methoxyphenyl)fumarate

There total 5 articles about (E)-4-ethyl 1-methyl 2-(4-methoxyphenyl)fumarate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 623-73-4
diazoacetic acid ethyl ester

: 22979-36-8
methyl 2-diazo-2-(4-methoxypheny)acetate

: 1285704-80-4
(E)-4-ethyl 1-methyl 2-(4-methoxyphenyl)fumarate

Guidance literature:: In dichloromethane; at 20 ℃; for 12h; Irradiation; Inert atmosphere;
DOI:10.1039/c8cc04609c

Reference yield:

: 23786-14-3
4-methoxy-phenyl acetic acid methyl ester

: 1285704-80-4
(E)-4-ethyl 1-methyl 2-(4-methoxyphenyl)fumarate

Guidance literature:: Multi-step reaction with 2 steps

1: 1,8-diazabicyclo[5.4.0]undec-7-ene; 4-acetamidobenzenesulfonyl azide / acetonitrile / 24.5 h / 0 - 23 °C / Inert atmosphere

2: sodium bromide; dirhodium cofactor covalently linked to prolyl oligopeptidase scaffold containing a genetically encoded azidophenylalanine (Z) residue at position 477 mutant 5-G / tetrahydrofuran / 22 h / 4 °C / pH 7.4 / Enzymatic reaction

With 4-acetamidobenzenesulfonyl azide; dirhodium cofactor covalently linked to prolyl oligopeptidase scaffold containing a genetically encoded azidophenylalanine (Z) residue at position 477 mutant 5-G; 1,8-diazabicyclo[5.4.0]undec-7-ene; sodium bromide; In tetrahydrofuran; acetonitrile;
DOI:10.1002/anie.202107982

Reference yield:

: 23786-14-3
4-methoxy-phenyl acetic acid methyl ester

: 1285704-80-4
(E)-4-ethyl 1-methyl 2-(4-methoxyphenyl)fumarate

: 13305-14-1
methyl 2-hydroxy-2-(4-methoxyphenyl)acetate

: 4-ethyl 1-methyl 2-(4-methoxyphenyl)fumarate

Guidance literature:: Multi-step reaction with 2 steps

1: 1,8-diazabicyclo[5.4.0]undec-7-ene; 4-acetamidobenzenesulfonyl azide / acetonitrile / 24.5 h / 0 - 23 °C / Inert atmosphere

2: sodium bromide; dirhodium cofactor covalently linked to prolyl oligopeptidase scaffold containing a genetically encoded azidophenylalanine (Z) residue at position 477 mutant 5-G / tetrahydrofuran / 22 h / 4 °C / pH 7.4 / Enzymatic reaction

With 4-acetamidobenzenesulfonyl azide; dirhodium cofactor covalently linked to prolyl oligopeptidase scaffold containing a genetically encoded azidophenylalanine (Z) residue at position 477 mutant 5-G; 1,8-diazabicyclo[5.4.0]undec-7-ene; sodium bromide; In tetrahydrofuran; acetonitrile;
DOI:10.1002/anie.202107982