methyl 2-[(5-chloro-2-methoxyphenyl)(acetoxy)methyl]propenoate

Base Information

• Chemical Name: methyl 2-[(5-chloro-2-methoxyphenyl)(acetoxy)methyl]propenoate
• CAS No.: 889855-38-3
• Molecular Formula: C₁₄H₁₅ClO₅
• Molecular Weight: 298.723
• Mol file: 889855-38-3.mol

Synonyms:methyl 2-[(5-chloro-2-methoxyphenyl)(acetoxy)methyl]propenoate

Chemical Property of methyl 2-[(5-chloro-2-methoxyphenyl)(acetoxy)methyl]propenoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of methyl 2-[(5-chloro-2-methoxyphenyl)(acetoxy)methyl]propenoate

There total 2 articles about methyl 2-[(5-chloro-2-methoxyphenyl)(acetoxy)methyl]propenoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 2-[(5-chloro-2-methoxyphenyl)(hydroxy)methyl]propenoate (889855-37-2) + acetyl chloride (75-36-5) → methyl 2-[(5-chloro-2-methoxyphenyl)(acetoxy)methyl]propenoate (889855-38-3)

Guidance literature:

With pyridine; In dichloromethane; at 0 ℃; for 1h;

Reference yield:

5-chloro-2-methoxybenzaldehyde (7035-09-8) → methyl 2-[(5-chloro-2-methoxyphenyl)(acetoxy)methyl]propenoate (889855-38-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 1,4-diaza-bicyclo[2.2.2]octane; lanthanum(lll) triflate; 2,2'-iminobis[ethanol] / 60 h / 20 °C

2: triethylamine; pyridine / dichloromethane / 1 h / 0 °C

With pyridine; 1,4-diaza-bicyclo[2.2.2]octane; triethylamine; 2,2'-iminobis[ethanol]; lanthanum(lll) triflate; In dichloromethane; 1: |Baylis-Hillman Reaction;

DOI:10.1016/j.bmc.2013.04.079

Reference yield:

methyl 2-[(5-chloro-2-methoxyphenyl)(acetoxy)methyl]propenoate (889855-38-3) → methyl (2E)-2-(azidomethyl)-3-(5-chloro-2-methoxyphenyl)-2-propenoate (889855-39-4)

Guidance literature:

With sodium azide; In dimethyl sulfoxide; at 20 ℃; for 0.5h;

upstream raw materials:

methyl 2-[(5-chloro-2-methoxyphenyl)(hydroxy)methyl]propenoate

acetyl chloride

5-chloro-2-methoxybenzaldehyde

Downstream raw materials:

methyl (2E)-2-(azidomethyl)-3-(5-chloro-2-methoxyphenyl)-2-propenoate

[((2E)-3-(5-chloro-2-methoxyphenyl)-2-{[(2,4,6-trimethoxybenzyl)amino]methyl}-2-propenyl)amino]ethyl acetate hydrochloride

C₂₃H₂₇ClN₂O₇*ClH

(6E)-6-(5-chloro-2-methoxybenzylidene)-1-(2,4,6-trimethoxybenzyl)-1,4-diazepan-2,5-dione