Technology Process of methyl 2-[(5-chloro-2-methoxyphenyl)(hydroxy)methyl]propenoate
There total 1 articles about methyl 2-[(5-chloro-2-methoxyphenyl)(hydroxy)methyl]propenoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
1,4-diaza-bicyclo[2.2.2]octane; 2,2'-iminobis[ethanol]; lanthanum(lll) triflate;
at 20 ℃;
for 60h;
- Guidance literature:
-
With
pyridine;
In
dichloromethane;
at 0 ℃;
for 1h;
- Guidance literature:
-
Multi-step reaction with 10 steps
1: triethylamine; pyridine / dichloromethane / 1 h / 0 °C
2: sodium azide / dimethyl sulfoxide / 0.5 h / 20 °C
3: triphenylphosphine / tetrahydrofuran; water / 15 h / 20 °C
4: sodium hydroxide; water / methanol / 2 h / 20 °C
5: sodium hydroxide; water / tetrahydrofuran / 1 h / 20 °C
6: triethylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 2 h / 20 °C / Cooling with ice
7: hydrogenchloride / ethyl acetate / 0.33 h / 20 °C
8: tetrahydrofuran / 0.33 h / 20 °C
9: sodium tris(acetoxy)borohydride / tetrahydrofuran / 1 h / 20 °C
10: sodium hydroxide; water / methanol / 2 h / 20 °C
With
pyridine; hydrogenchloride; sodium azide; water; sodium tris(acetoxy)borohydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; triphenylphosphine; sodium hydroxide;
In
tetrahydrofuran; methanol; dichloromethane; water; dimethyl sulfoxide; ethyl acetate;
DOI:10.1016/j.bmc.2013.04.079
