ethyl 2-{[2-(methylamino)-2-oxoethyl]thio}-4-phenyl-1,3-thiazole-5-carboxylate

Base Information

• Chemical Name: ethyl 2-{[2-(methylamino)-2-oxoethyl]thio}-4-phenyl-1,3-thiazole-5-carboxylate
• CAS No.: 906099-54-5
• Molecular Formula: C₁₅H₁₆N₂O₃S₂
• Molecular Weight: 336.436
• Mol file: 906099-54-5.mol

Synonyms:ethyl 2-{[2-(methylamino)-2-oxoethyl]thio}-4-phenyl-1,3-thiazole-5-carboxylate

Chemical Property of ethyl 2-{[2-(methylamino)-2-oxoethyl]thio}-4-phenyl-1,3-thiazole-5-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 2-{[2-(methylamino)-2-oxoethyl]thio}-4-phenyl-1,3-thiazole-5-carboxylate

There total 1 articles about ethyl 2-{[2-(methylamino)-2-oxoethyl]thio}-4-phenyl-1,3-thiazole-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl-2-bromo-4-phenyl-1,3-thiazol-5-carboxylate (177328-30-2) + mercapto-acetic acid methylamide (20938-74-3) → ethyl 2-{[2-(methylamino)-2-oxoethyl]thio}-4-phenyl-1,3-thiazole-5-carboxylate (906099-54-5)

Guidance literature:

With caesium carbonate; In acetone; at 50 ℃; for 4h;

Reference yield:

ethyl 2-{[2-(methylamino)-2-oxoethyl]thio}-4-phenyl-1,3-thiazole-5-carboxylate (906099-54-5) → 2-{[2-(methylamino)-2-oxoethyl]thio}-4-phenyl-1,3-thiazole-5-carboxylic acid (906099-55-6)

Guidance literature:

ethyl 2-{[2-(methylamino)-2-oxoethyl]thio}-4-phenyl-1,3-thiazole-5-carboxylate; With methanol; sodium hydroxide; water; at 20 ℃; for 3h;

With hydrogenchloride; pH=2;

Reference yield:

4-Chlorobenzenesulfonamide (98-64-6) + ethyl 2-{[2-(methylamino)-2-oxoethyl]thio}-4-phenyl-1,3-thiazole-5-carboxylate (906099-54-5) → 2-({5-[({[(4-chlorophenyl)sulfonyl]amino}carbonyl)amino]-4-phenyl-1,3-thiazol-2-yl}thio)-N-niethylacetamide

Guidance literature:

With diphenyl phosphoryl azide; N-ethyl-N,N-diisopropylamine; In benzene; for 1h; Heating / reflux;

upstream raw materials:

ethyl-2-bromo-4-phenyl-1,3-thiazol-5-carboxylate

mercapto-acetic acid methylamide

Downstream raw materials:

2-{[2-(methylamino)-2-oxoethyl]thio}-4-phenyl-1,3-thiazole-5-carboxylic acid