N-methyl-2-sulfanylacetamide

Base Information

• Chemical Name: N-methyl-2-sulfanylacetamide
• CAS No.: 20938-74-3
• Molecular Formula: C3H7NOS
• Molecular Weight: 105.161
• Hs Code.: 29309090
• European Community (EC) Number: 629-060-1
• DSSTox Substance ID: DTXSID90902428
• Nikkaji Number: J1.827.153B
• Wikidata: Q27117967
• Metabolomics Workbench ID: 55987
• Mol file: 20938-74-3.mol

Synonyms:N-(Methyl)mercaptoacetamide;20938-74-3;N-methyl-2-sulfanylacetamide;2-mercapto-N-methylacetamide;N-Methylthioglycolamide;Acetamide, 2-mercapto-N-methyl-;n-methyl-mercaptoacetamide;thioglycolic methylamide;NoName_1671;N-methyl-2-mercaptoacetamide;SCHEMBL314398;CHEBI:38731;DTXSID90902428;MFCD00042981;AKOS006223246;AS-80692;FT-0660558;EN300-200189;N-(Methyl)mercaptoacetamide, >=97.0% (RT);A919357;J-013729;Q27117967;F8886-4364;Z1203730878

Chemical Property of N-methyl-2-sulfanylacetamide

Chemical Property:

• Vapor Pressure: 0.00411mmHg at 25°C
• Melting Point: 58℃
• Refractive Index: n20/D 1.523
• Boiling Point: 279 °C at 760 mmHg
• PKA: 8.12±0.10(Predicted)
• Flash Point: 122.6 °C
• PSA: 67.90000
• Density: 1.072 g/cm³
• LogP: 0.05310
• Storage Temp.: 2-8°C
• XLogP3: -0.1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 105.02483502
• Heavy Atom Count: 6
• Complexity: 54.8

Purity/Quality:

99%, ^*data from raw suppliers

N-methyl-2-sulfanylacetamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CNC(=O)CS
• Uses: A mild reducing agent for methionine sulfoxide

Technology Process of N-methyl-2-sulfanylacetamide

There total 6 articles about N-methyl-2-sulfanylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

3-(2-(4-bromophenyl)-2-oxoethyl)thiazolidine-2,4-dione (88419-02-7) + methylamine (74-89-5) → mercapto-acetic acid methylamide (20938-74-3) + 2,5-bis(4-bromophenyl)pyrazine (55453-06-0)

Guidance literature:

In methanol; water;

Reference yield: 60.0%

3-(2-oxo-2-phenylethyl)thiazolidine-2,4-dione (88419-01-6) → 2,5-diphenylpyrazine (5398-63-0) + mercapto-acetic acid methylamide (20938-74-3)

Guidance literature:

With methylamine; In methanol; at 90 - 95 ℃; for 4h;

Reference yield: 60.0%

3-(2-oxo-2-phenylethyl)thiazolidine-2,4-dione (88419-01-6) + methylamine (74-89-5) → 2,5-diphenylpyrazine (5398-63-0) + mercapto-acetic acid methylamide (20938-74-3)

Guidance literature:

In methanol; at 90 - 95 ℃; for 4h;

upstream raw materials:

3-(2-oxo-2-phenylethyl)thiazolidine-2,4-dione

3-(2-(4-bromophenyl)-2-oxoethyl)thiazolidine-2,4-dione

methylamine

omethoate

Downstream raw materials:

<3-Chlor-4-methoxy-phenylcarbamoylmercapto>-essigsaeure-methylamid

<4-Aethoxycarbonyl-phenylcarbamoylmercapto>-essigsaeure-methylamid

3-amino-N-methylthiophene-2-carboxamide

2-acetylamino-3-phenyl-thiopropionic acid S-methylcarbamoylmethyl ester

Refernces

• 1、 Bai, Yanhong,Chen, Jierong,Mu, Hui,Zhang, Chunhong,Li, Baoping. "Reduction of dichlorvos and omethoate residues by O2 plasma treatment". experimental part. p. 6238 - 6245. Retrieved 2010/07/06.