2-BROMO-4-PHENYL-5-THIAZOLECARBOXYLIC ACID ETHYL ESTER

Base Information

• Chemical Name: 2-BROMO-4-PHENYL-5-THIAZOLECARBOXYLIC ACID ETHYL ESTER
• CAS No.: 177328-30-2
• Molecular Formula: C12H10BrNO2S
• Molecular Weight: 312.187
• Mol file: 177328-30-2.mol

Synonyms:ethyl-2-bromo-4-phenyl-1,3-thiazol-5-carboxylate;BB_SC-8744;ethyl 2-bromo-4-phenylthiazole-5-carboxylate;

Chemical Property of 2-BROMO-4-PHENYL-5-THIAZOLECARBOXYLIC ACID ETHYL ESTER

Chemical Property:

• PSA: 67.43000
• LogP: 3.74930

Purity/Quality:

99% ，98% ^*data from raw suppliers

Ethyl2-bromo-4-phenylthiazole-5-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-BROMO-4-PHENYL-5-THIAZOLECARBOXYLIC ACID ETHYL ESTER

There total 3 articles about 2-BROMO-4-PHENYL-5-THIAZOLECARBOXYLIC ACID ETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

ethyl 4-phenyl-2-aminothiazole-5-carboxylate (64399-23-1) → ethyl-2-bromo-4-phenyl-1,3-thiazol-5-carboxylate (177328-30-2)

Guidance literature:

With tert.-butylnitrite; copper(I) bromide; In acetonitrile; at 0 - 20 ℃; for 16h; Inert atmosphere;

Reference yield:

ethyl 2-bromo-3-oxo-3-phenylpropionate (55919-47-6) → ethyl-2-bromo-4-phenyl-1,3-thiazol-5-carboxylate (177328-30-2)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol / 4 h / Reflux

2: copper(I) bromide; tert.-butylnitrite / acetonitrile / 16 h / 0 - 20 °C / Inert atmosphere

With tert.-butylnitrite; copper(I) bromide; In ethanol; acetonitrile;

Reference yield:

→ ethyl-2-bromo-4-phenyl-1,3-thiazol-5-carboxylate (177328-30-2)

Guidance literature:

upstream raw materials:

ethyl 4-phenyl-2-aminothiazole-5-carboxylate

ethyl 2-bromo-3-oxo-3-phenylpropionate

Downstream raw materials:

ethyl 2-{[2-(methylamino)-2-oxoethyl]thio}-4-phenyl-1,3-thiazole-5-carboxylate

2-bromo-4-phenylthiazole-5-carboxylic acid

2-ethoxy-4-phenyl-1,3-thiazole-5-carboxylic acid

2-(2-methylpyrimidin-5-yl)-4-phenylthiazole-5-carboxylic acid