(N-tert-butoxycarbonyl-D-1,2,3,4-tetrahydroisoquinoline-3-carbonyl)-4-chloro-D-phenylalanine 4-nitrobenzyl ester

Base Information

Chemical Name:(N-tert-butoxycarbonyl-D-1,2,3,4-tetrahydroisoquinoline-3-carbonyl)-4-chloro-D-phenylalanine 4-nitrobenzyl ester
CAS No.:766550-04-3
Molecular Formula:C₃₁H₃₂ClN₃O₇
Molecular Weight:594.064
Hs Code.:

Synonyms:(N-tert-butoxycarbonyl-D-1,2,3,4-tetrahydroisoquinoline-3-carbonyl)-4-chloro-D-phenylalanine 4-nitrobenzyl ester

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Chemical Property of (N-tert-butoxycarbonyl-D-1,2,3,4-tetrahydroisoquinoline-3-carbonyl)-4-chloro-D-phenylalanine 4-nitrobenzyl ester

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Technology Process of (N-tert-butoxycarbonyl-D-1,2,3,4-tetrahydroisoquinoline-3-carbonyl)-4-chloro-D-phenylalanine 4-nitrobenzyl ester

There total 4 articles about (N-tert-butoxycarbonyl-D-1,2,3,4-tetrahydroisoquinoline-3-carbonyl)-4-chloro-D-phenylalanine 4-nitrobenzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 78879-20-6,144069-68-1,115962-35-1
D-N-tert-butoxycarbonyl-1,2,3,4-tetrahydroisoquinolinoline-3-carboxylic acid

: 4-chloro-D-phenylalanine 4-nitrobenzyl ester hydrochloride

: 766550-04-3
(N-tert-butoxycarbonyl-D-1,2,3,4-tetrahydroisoquinoline-3-carbonyl)-4-chloro-D-phenylalanine 4-nitrobenzyl ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃; for 2h;
DOI:10.1021/jm0311285

Reference yield:

: 57292-44-1
N-Boc-D-(4-Cl)Phe-OH

: 766550-04-3
(N-tert-butoxycarbonyl-D-1,2,3,4-tetrahydroisoquinoline-3-carbonyl)-4-chloro-D-phenylalanine 4-nitrobenzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 89 percent / TEA / ethyl acetate / 7 h / Heating

2: 96 percent / AcOH; HCl / dioxane / 1 h / 20 °C

3: 99 percent / HATU; DIEA / dimethylformamide / 2 h / 20 °C

With hydrogenchloride; TEA; acetic acid; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In 1,4-dioxane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm0311285

Reference yield:

: 100-11-8
1-bromomethyl-4-nitro-benzene

: 766550-04-3
(N-tert-butoxycarbonyl-D-1,2,3,4-tetrahydroisoquinoline-3-carbonyl)-4-chloro-D-phenylalanine 4-nitrobenzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 89 percent / TEA / ethyl acetate / 7 h / Heating

2: 96 percent / AcOH; HCl / dioxane / 1 h / 20 °C

3: 99 percent / HATU; DIEA / dimethylformamide / 2 h / 20 °C

With hydrogenchloride; TEA; acetic acid; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In 1,4-dioxane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm0311285