(R)-1-[((R)-1-phenylethyl)aziridin-2-yl]methyl 4-methylbenzenesulfonate

Base Information

• Chemical Name: (R)-1-[((R)-1-phenylethyl)aziridin-2-yl]methyl 4-methylbenzenesulfonate
• CAS No.: 887947-03-7
• Molecular Formula: C₁₈H₂₁NO₃S
• Molecular Weight: 331.436

Synonyms:(R)-1-[((R)-1-phenylethyl)aziridin-2-yl]methyl 4-methylbenzenesulfonate

Chemical Property of (R)-1-[((R)-1-phenylethyl)aziridin-2-yl]methyl 4-methylbenzenesulfonate

Chemical Property:

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Technology Process of (R)-1-[((R)-1-phenylethyl)aziridin-2-yl]methyl 4-methylbenzenesulfonate

There total 1 articles about (R)-1-[((R)-1-phenylethyl)aziridin-2-yl]methyl 4-methylbenzenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

p-toluenesulfonyl chloride (98-59-9) + (1R,2R)-1-(α-methylbenzyl)-2-(hydroxymethyl)aziridine (173034-70-3) → (R)-1-[((R)-1-phenylethyl)aziridin-2-yl]methyl 4-methylbenzenesulfonate (887947-03-7)

Guidance literature:

With dmap; triethylamine; In dichloromethane; at 0 - 20 ℃; for 4h;

DOI:10.1021/jo201255z

Reference yield: 95.0%

(R)-1-[((R)-1-phenylethyl)aziridin-2-yl]methyl 4-methylbenzenesulfonate (887947-03-7) + 2-bromo-4-fluoro-phenol (496-69-5) → (R)-2-[(2-bromo-4-fluorophenoxy)methyl]-1-[(R)-1-phenylethyl]aziridine (1252059-89-4)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; acetone; Inert atmosphere; Reflux;

DOI:10.1016/j.tet.2010.07.027

Reference yield: 90.0%

(R)-1-[((R)-1-phenylethyl)aziridin-2-yl]methyl 4-methylbenzenesulfonate (887947-03-7) + 3-bromo-2-naphthol (30478-88-7) → (R)-2-[(3-bromonaphthalen-2-yloxy)methyl]-1-[(R)-1-phenylethyl]aziridine (1252059-90-7)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; acetone; Inert atmosphere; Reflux;

DOI:10.1016/j.tet.2010.07.027

upstream raw materials:

p-toluenesulfonyl chloride

(1R,2R)-1-(α-methylbenzyl)-2-(hydroxymethyl)aziridine

Downstream raw materials:

(2S)-(azidomethyl)-1-[(R)-1-phenylethyl]aziridine

(2R)-(azidomethyl)-1-[(R)-1-phenylethyl]aziridine

(2S)-[(2,6-dimethylphenoxy)methyl]-1-[(R)-1-phenylethyl]aziridine

(R)-2-[(2,6-dimethylphenoxy)methyl]-1-[(R)-1-phenylethyl]aziridine

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