N²-[4-tert-butyloxy-3S-(2-cyanobenzene-1-sulfonylamino)-2R-isobutylsuccinyl]-L-tert-leucine-N¹-methylamide

Base Information

• Chemical Name: N²-[4-tert-butyloxy-3S-(2-cyanobenzene-1-sulfonylamino)-2R-isobutylsuccinyl]-L-tert-leucine-N¹-methylamide
• CAS No.: 204126-20-5
• Molecular Formula: C₂₆H₄₀N₄O₆S
• Molecular Weight: 536.693

Synonyms:N²-[4-tert-butyloxy-3S-(2-cyanobenzene-1-sulfonylamino)-2R-isobutylsuccinyl]-L-tert-leucine-N¹-methylamide

Chemical Property of N²-[4-tert-butyloxy-3S-(2-cyanobenzene-1-sulfonylamino)-2R-isobutylsuccinyl]-L-tert-leucine-N¹-methylamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N²-[4-tert-butyloxy-3S-(2-cyanobenzene-1-sulfonylamino)-2R-isobutylsuccinyl]-L-tert-leucine-N¹-methylamide

There total 1 articles about N²-[4-tert-butyloxy-3S-(2-cyanobenzene-1-sulfonylamino)-2R-isobutylsuccinyl]-L-tert-leucine-N¹-methylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

2-cyanobenzenesulfonyl chloride (69360-26-5) + (2S,3R)-2-Amino-3-((S)-2,2-dimethyl-1-methylcarbamoyl-propylcarbamoyl)-5-methyl-hexanoic acid tert-butyl ester → N2-[4-tert-butyloxy-3S-(2-cyanobenzene-1-sulfonylamino)-2R-isobutylsuccinyl]-L-tert-leucine-N1-methylamide (204126-20-5)

Guidance literature:

With pyridine; dmap; In dichloromethane; at 20 ℃;

DOI:10.1021/jm990377j

Reference yield: 93.0%

N2-[4-tert-butyloxy-3S-(2-cyanobenzene-1-sulfonylamino)-2R-isobutylsuccinyl]-L-tert-leucine-N1-methylamide (204126-20-5) → (2S,3R)-2-(2-Cyano-benzenesulfonylamino)-3-((S)-2,2-dimethyl-1-methylcarbamoyl-propylcarbamoyl)-5-methyl-hexanoic acid (204126-19-2)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 0 ℃;

DOI:10.1021/jm990377j

Reference yield:

N2-[4-tert-butyloxy-3S-(2-cyanobenzene-1-sulfonylamino)-2R-isobutylsuccinyl]-L-tert-leucine-N1-methylamide (204126-20-5) → 2-(2-cyano-benzenesulfonylamino)-N4-(2,2-dimethyl-1-methylcarbamoyl-propyl)-N1-hydroxy-3-isobutyl-succinamide

Guidance literature:

Multi-step reaction with 2 steps

1: 93 percent / TFA / CH₂Cl₂ / 0 °C

2: 52 percent / tBuMe₂SiONH₂; 2-ethoxy-1-ethoxycarbonyl-1,2-dihydroquinoline / CHCl₃ / 18 h

With O-(tert-butyldimethylsilanyl)hydroxylamine; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; trifluoroacetic acid; In dichloromethane; chloroform; 1: acidolysis / 2: Condensation;

DOI:10.1021/jm990377j

upstream raw materials:

2-cyanobenzenesulfonyl chloride

Downstream raw materials:

(2S,3R)-2-(2-Cyano-benzenesulfonylamino)-3-((S)-2,2-dimethyl-1-methylcarbamoyl-propylcarbamoyl)-5-methyl-hexanoic acid

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 204126-20-5 N²-[4-tert-butyloxy-3S-(2-cyanobenzene-1-sulfonylamino)-2R-isobutylsuccinyl]-L-tert-leucine-N¹-methylamide

Send

Send

Metric Ton KG G Pound L ML

Send

Send