2-Cyanobenzenesulphonyl chloride

Base Information

• Chemical Name: 2-Cyanobenzenesulphonyl chloride
• CAS No.: 69360-26-5
• Molecular Formula: C7H4ClNO2S
• Molecular Weight: 201.633
• Hs Code.: 29269090
• Mol file: 69360-26-5.mol

Synonyms:Benzenesulfonylchloride, o-cyano- (6CI,7CI);2-Cyanobenzene-1-sulfonyl chloride;2-Cyanobenzenesulfonyl chloride;2-Cyanobenzensulfonyl chloride;2-Cyanophenylsulfonyl chloride;

Chemical Property of 2-Cyanobenzenesulphonyl chloride

Chemical Property:

• Appearance/Colour: beige crystalline powder
• Vapor Pressure: 4.25E-05mmHg at 25°C
• Melting Point: 65-69 °C(lit.)
• Refractive Index: 1.6
• Boiling Point: 350.9 °C at 760 mmHg
• Flash Point: 166 °C
• PSA: 66.31000
• Density: 1.53 g/cm³
• LogP: 2.56658
• Storage Temp.: Inert atmosphere,Room Temperature
• Sensitive.: Moisture Sensitive

Purity/Quality:

99.5% ^*data from raw suppliers

2-Cyanobenzenesulfonyl Chloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C
• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-36/37/39-45

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-Cyanobenzenesulfonyl chloride may be used in the synthesis of:2-butyl-5-(2-cyanophenyl)furan2-(2-cyanophenyl)-3,6-dimethyl-4,5,6,7-tetrahydrobenzofuran5-thia-4b,10-diaza-indeno[2,1-a]indene-5,5-dioxide1-methyl-2-(2-cyanophenyl)pyrrole

Technology Process of 2-Cyanobenzenesulphonyl chloride

There total 8 articles about 2-Cyanobenzenesulphonyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

N-chloro-succinimide (128-09-6) + ethanol (64-17-5) + o-benzyl mercapto-benzonitrile (63216-04-6) → Succinimide (123-56-8,89963-74-6) + 2-cyanobenzenesulfonyl chloride (69360-26-5) + benzyl chloride (100-44-7) + 2-Cyano-benzenesulfinic acid ethyl ester

Guidance literature:

In chloroform; for 18h; Product distribution; Ambient temperature;

DOI:10.1021/jo961565+

Reference yield: 62.0%

o-benzyl mercapto-benzonitrile (63216-04-6) → 2-cyanobenzenesulfonyl chloride (69360-26-5)

Guidance literature:

With N-chloro-succinimide; In dichloromethane; benzyl alcohol; for 59h; Ambient temperature;

DOI:10.1021/jo961565+

Reference yield: 59.0%

N-chloro-succinimide (128-09-6) + o-benzyl mercapto-benzonitrile (63216-04-6) + benzyl alcohol (100-51-6,185532-71-2) → Succinimide (123-56-8,89963-74-6) + 2-cyanobenzenesulfonyl chloride (69360-26-5) + benzyl chloride (100-44-7)

Guidance literature:

With N-chloro-succinimide; In dichloromethane; for 18h; Product distribution; Ambient temperature;

DOI:10.1021/jo961565+

upstream raw materials:

saccharin

N-chloro-succinimide

ethanol

o-benzyl mercapto-benzonitrile

Downstream raw materials:

2-(2-cyano-benzenesulfonylamino)-3-[4-(2-methoxycarbonyl-ethyl)-benzoylamino]-propionic acid tert-butyl ester

2-cyano-N-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-N-[3-(tetrahydro-pyran-2-yloxy)-benzyl]-benzenesulfonamide

N-(4-(1-acetyl-3-(3,4-dimethoxyphenyl)-4, 5-dihydro-1H-pyrazol-5-yl)phenyl)-2-cyanobenzenesulfonamide

Refernces

• 1、 Xia, Mingde,Chen, Shaowu,Bates, Dallas K.. "Reactions of benzyl aryl sulfides with excess active halogen reagents". . p. 9289 - 9292. Retrieved 2007/10/03.