2-(4-chlorophenyl)-4-[1-(4-ethoxyphenyl)-5-methyl-1H-1,2,3-triazol-4-yl]-4-oxobutyronitrile

Base Information

Chemical Name:2-(4-chlorophenyl)-4-[1-(4-ethoxyphenyl)-5-methyl-1H-1,2,3-triazol-4-yl]-4-oxobutyronitrile
CAS No.:1616890-31-3
Molecular Formula:C₂₁H₁₉ClN₄O₂
Molecular Weight:394.86
Hs Code.:

Synonyms:2-(4-chlorophenyl)-4-[1-(4-ethoxyphenyl)-5-methyl-1H-1,2,3-triazol-4-yl]-4-oxobutyronitrile

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Chemical Property of 2-(4-chlorophenyl)-4-[1-(4-ethoxyphenyl)-5-methyl-1H-1,2,3-triazol-4-yl]-4-oxobutyronitrile

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Technology Process of 2-(4-chlorophenyl)-4-[1-(4-ethoxyphenyl)-5-methyl-1H-1,2,3-triazol-4-yl]-4-oxobutyronitrile

There total 4 articles about 2-(4-chlorophenyl)-4-[1-(4-ethoxyphenyl)-5-methyl-1H-1,2,3-triazol-4-yl]-4-oxobutyronitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 1616890-22-2
(E)-3-(4-chlorophenyl)-1-[1-(4-ethoxyphenyl)-5-methyl-1H-1,2,3-triazol-4-yl]prop-2-en-1-one

: 109-77-3
malononitrile

: 1616890-31-3
2-(4-chlorophenyl)-4-[1-(4-ethoxyphenyl)-5-methyl-1H-1,2,3-triazol-4-yl]-4-oxobutyronitrile

Guidance literature:: With potassium fluoride on basic alumina; In N,N-dimethyl-formamide; at 90 - 100 ℃; for 6h; Green chemistry;
DOI:10.1039/c4gc00386a

Reference yield:

: 123-54-6,81235-32-7
acetylacetone

: 1616890-31-3
2-(4-chlorophenyl)-4-[1-(4-ethoxyphenyl)-5-methyl-1H-1,2,3-triazol-4-yl]-4-oxobutyronitrile

Guidance literature:: Multi-step reaction with 3 steps

1: sodium methylate / methanol / 11 h / 0 - 5 °C / Reflux

2: potassium hydroxide / ethanol; water / 6 h / 0 - 25 °C

3: potassium fluoride on basic alumina / N,N-dimethyl-formamide / 6 h / 90 - 100 °C / Green chemistry

With potassium fluoride on basic alumina; sodium methylate; potassium hydroxide; In methanol; ethanol; water; N,N-dimethyl-formamide; 3: |Michael Addition;
DOI:10.1039/c4gc00386a

Reference yield:

: 98488-09-6
1-azido-4-ethoxybenzene

: 1616890-31-3
2-(4-chlorophenyl)-4-[1-(4-ethoxyphenyl)-5-methyl-1H-1,2,3-triazol-4-yl]-4-oxobutyronitrile

Guidance literature:: Multi-step reaction with 3 steps

1: sodium methylate / methanol / 11 h / 0 - 5 °C / Reflux

2: potassium hydroxide / ethanol; water / 6 h / 0 - 25 °C

3: potassium fluoride on basic alumina / N,N-dimethyl-formamide / 6 h / 90 - 100 °C / Green chemistry

With potassium fluoride on basic alumina; sodium methylate; potassium hydroxide; In methanol; ethanol; water; N,N-dimethyl-formamide; 3: |Michael Addition;
DOI:10.1039/c4gc00386a