tert-butyl (3-((5-acetyl-2-(methylthio)pyrimidin-4-yl)amino)phenyl)carbamate

Base Information

Chemical Name:tert-butyl (3-((5-acetyl-2-(methylthio)pyrimidin-4-yl)amino)phenyl)carbamate
CAS No.:1584151-18-7
Molecular Formula:C₁₈H₂₂N₄O₃S
Molecular Weight:374.464
Hs Code.:

Synonyms:tert-butyl (3-((5-acetyl-2-(methylthio)pyrimidin-4-yl)amino)phenyl)carbamate

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Chemical Property of tert-butyl (3-((5-acetyl-2-(methylthio)pyrimidin-4-yl)amino)phenyl)carbamate

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Technology Process of tert-butyl (3-((5-acetyl-2-(methylthio)pyrimidin-4-yl)amino)phenyl)carbamate

There total 6 articles about tert-butyl (3-((5-acetyl-2-(methylthio)pyrimidin-4-yl)amino)phenyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 1625677-96-4
tert-butyl (3-((5-(1-hydroxyethyl)-2-(methylthio)pyrimidin-4-yl)amino)phenyl)carbamate

: 1584151-18-7
tert-butyl (3-((5-acetyl-2-(methylthio)pyrimidin-4-yl)amino)phenyl)carbamate

Guidance literature:: With manganese(IV) oxide; In chloroform; at 60 ℃; for 16h;
DOI:10.1021/acsmedchemlett.5b00193

Reference yield:

: 1363161-16-3
tert-butyl 3-(5-(formyl)-2-(methylmercapto)pyrimidine-4-ylamino)phenylcarbamate

: 1584151-18-7
tert-butyl (3-((5-acetyl-2-(methylthio)pyrimidin-4-yl)amino)phenyl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: tetrahydrofuran; diethyl ether / 2.08 h / 0.5 - 8 °C / Inert atmosphere

2: tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide / dichloromethane / 3 h / 20 °C

With tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide; In tetrahydrofuran; diethyl ether; dichloromethane;

Reference yield:

: 1363161-14-1
ethyl 4-((3-((tert-butoxycarbonyl)amino)phenyl)amino)-2-(methylthio)pyrimidine-5-carboxylate

: 1584151-18-7
tert-butyl (3-((5-acetyl-2-(methylthio)pyrimidin-4-yl)amino)phenyl)carbamate

Guidance literature:: Multi-step reaction with 4 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 13 h / -40 - 0 °C

2: manganese(IV) oxide / chloroform / 18 h / 20 °C

3: tetrahydrofuran; diethyl ether / 2.08 h / 0.5 - 8 °C / Inert atmosphere

4: tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide / dichloromethane / 3 h / 20 °C

With manganese(IV) oxide; lithium aluminium tetrahydride; tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide; In tetrahydrofuran; diethyl ether; dichloromethane; chloroform;