tert-butyl (3-((5-(1-hydroxyethyl)-2-(methylthio)pyrimidin-4-yl)amino)phenyl)carbamate

Base Information

Chemical Name:tert-butyl (3-((5-(1-hydroxyethyl)-2-(methylthio)pyrimidin-4-yl)amino)phenyl)carbamate
CAS No.:1625677-96-4
Molecular Formula:C₁₈H₂₄N₄O₃S
Molecular Weight:376.48
Hs Code.:

Synonyms:tert-butyl (3-((5-(1-hydroxyethyl)-2-(methylthio)pyrimidin-4-yl)amino)phenyl)carbamate

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Chemical Property of tert-butyl (3-((5-(1-hydroxyethyl)-2-(methylthio)pyrimidin-4-yl)amino)phenyl)carbamate

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Technology Process of tert-butyl (3-((5-(1-hydroxyethyl)-2-(methylthio)pyrimidin-4-yl)amino)phenyl)carbamate

There total 6 articles about tert-butyl (3-((5-(1-hydroxyethyl)-2-(methylthio)pyrimidin-4-yl)amino)phenyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1363161-16-3
tert-butyl 3-(5-(formyl)-2-(methylmercapto)pyrimidine-4-ylamino)phenylcarbamate

: 75-16-1
methylmagnesium bromide

: 1625677-96-4
tert-butyl (3-((5-(1-hydroxyethyl)-2-(methylthio)pyrimidin-4-yl)amino)phenyl)carbamate

Guidance literature:: In tetrahydrofuran; diethyl ether; at 0.5 - 8 ℃; for 2.08333h; Inert atmosphere;

Reference yield: 89.0%

: 1363161-16-3
tert-butyl 3-(5-(formyl)-2-(methylmercapto)pyrimidine-4-ylamino)phenylcarbamate

: 2999-74-8
dimethylmagnesium

: 1625677-96-4
tert-butyl (3-((5-(1-hydroxyethyl)-2-(methylthio)pyrimidin-4-yl)amino)phenyl)carbamate

Guidance literature:: tert-butyl 3-(5-(formyl)-2-(methylmercapto)pyrimidine-4-ylamino)phenylcarbamate; dimethylmagnesium; In tetrahydrofuran; diethyl ether; at 0.5 - 20 ℃; for 2.08333h;

With ammonium chloride; In tetrahydrofuran; diethyl ether; water; Cooling with ice;
DOI:10.1021/acsmedchemlett.5b00193

Reference yield:

: 1363161-14-1
ethyl 4-((3-((tert-butoxycarbonyl)amino)phenyl)amino)-2-(methylthio)pyrimidine-5-carboxylate

: 1625677-96-4
tert-butyl (3-((5-(1-hydroxyethyl)-2-(methylthio)pyrimidin-4-yl)amino)phenyl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 13 h / -40 - 0 °C

2: manganese(IV) oxide / chloroform / 18 h / 20 °C

3: tetrahydrofuran; diethyl ether / 2.08 h / 0.5 - 8 °C / Inert atmosphere

With manganese(IV) oxide; lithium aluminium tetrahydride; In tetrahydrofuran; diethyl ether; chloroform;