Technology Process of bis<3-tert-butyl-5phenyl>nitroxide
There total 5 articles about bis<3-tert-butyl-5phenyl>nitroxide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 9.28 g / Br2, conc. HCl / H2O / 3 h
2: 69 percent / conc. H2SO4, NaNO2 / ethanol; benzene / 3 h / Heating
3: 1.) t-BuLi / 1.) THF, pentane, from -78 deg C to 0 deg C, 30 min, 2.) THF, pentane, from -78 deg C to RT, 1 h
4: 100 percent / imidazole / dimethylformamide / 12 h / 50 - 60 °C
5: 1.) t-BuLi, 2.) n-pentyl nitrite / 1.) THf, pentane, from -78 deg C to RT, 15 min, 2.) RT, 1 h
With
1H-imidazole; hydrogenchloride; n-Amyl nitrite; sulfuric acid; bromine; tert.-butyl lithium; sodium nitrite;
In
ethanol; water; N,N-dimethyl-formamide; benzene;
DOI:10.1021/ja00011a028
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1.) t-BuLi / 1.) THF, pentane, from -78 deg C to 0 deg C, 30 min, 2.) THF, pentane, from -78 deg C to RT, 1 h
2: 100 percent / imidazole / dimethylformamide / 12 h / 50 - 60 °C
3: 1.) t-BuLi, 2.) n-pentyl nitrite / 1.) THf, pentane, from -78 deg C to RT, 15 min, 2.) RT, 1 h
With
1H-imidazole; n-Amyl nitrite; tert.-butyl lithium;
In
N,N-dimethyl-formamide;
DOI:10.1021/ja00011a028
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 69 percent / conc. H2SO4, NaNO2 / ethanol; benzene / 3 h / Heating
2: 1.) t-BuLi / 1.) THF, pentane, from -78 deg C to 0 deg C, 30 min, 2.) THF, pentane, from -78 deg C to RT, 1 h
3: 100 percent / imidazole / dimethylformamide / 12 h / 50 - 60 °C
4: 1.) t-BuLi, 2.) n-pentyl nitrite / 1.) THf, pentane, from -78 deg C to RT, 15 min, 2.) RT, 1 h
With
1H-imidazole; n-Amyl nitrite; sulfuric acid; tert.-butyl lithium; sodium nitrite;
In
ethanol; N,N-dimethyl-formamide; benzene;
DOI:10.1021/ja00011a028
