2-bromo-4-nitropropiophenone

Base Information

• Chemical Name: 2-bromo-4-nitropropiophenone
• CAS No.: 1205-56-7
• Molecular Formula: C9H8 Br N O3
• Molecular Weight: 258.071
• Hs Code.: 2914700090
• Mol file: 1205-56-7.mol

Synonyms:Propiophenone,2-bromo-4'-nitro- (6CI,7CI,8CI)

Chemical Property of 2-bromo-4-nitropropiophenone

Chemical Property:

• PSA: 62.89000
• LogP: 3.08410

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-BROMO-4'-NITROPROPIOPHENONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-bromo-4-nitropropiophenone

There total 4 articles about 2-bromo-4-nitropropiophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1-(4-nitrophenyl)propan-1-one (3758-70-1) → 2-bromo-1-(4-nitrophenyl)propan-1-one (1205-56-7)

Guidance literature:

With bromine; In tetrachloromethane; at 20 ℃; for 1.5h;

Reference yield: 61.0%

(1-nitro-4-(prop-1-en-1-yl)benzene) (25798-60-1) → 1-<(4-nitro)-phenyl>-1,2-propandione (6159-25-7) + 2-bromo-1-(4-nitrophenyl)propan-1-one (1205-56-7)

Guidance literature:

With N-Bromosuccinimide; dimethyl sulfoxide; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; at 60 - 65 ℃; for 2.5h; Mechanism;

DOI:10.1016/j.tetlet.2009.03.032

Reference yield:

(1-nitro-4-(prop-1-en-1-yl)benzene) (25798-60-1) → 2-bromo-1-(4-nitrophenyl)propan-1-one (1205-56-7)

Guidance literature:

With N-Bromosuccinimide; water; at 80 ℃; for 2h; Inert atmosphere; Green chemistry;

DOI:10.1039/c5gc02771c

upstream raw materials:

1-(4-nitrophenyl)propan-1-one

(1-nitro-4-(prop-1-en-1-yl)benzene)

Downstream raw materials:

2-hydroxy-1-<(4-nitro)-phenyl>-1-propanone

5-methyl-4-(4-nitrophenyl)-2-phenylthiazole

2-amino-4-(4’-nitrophenyl)-5-methyl-1,3-thiazole

2-[5-Methyl-4-(4-nitro-phenyl)-thiazol-2-yl]-pyridine

Refernces

• 1、 Shinde, Mahesh H.,Kshirsagar, Umesh A.. "One pot synthesis of substituted imidazopyridines and thiazoles from styrenes in water assisted by NBS". supporting information. p. 1455 - 1458. Retrieved 2016/04/04.
• 2、 Moorthy, Jarugu Narasimha,Senapati, Kalyan,Singhal, Nidhi. "An expedient protocol for conversion of olefins to α-bromo/iodoketones using IBX and NBS/NIS". experimental part. p. 2493 - 2496. Retrieved 2009/08/17.