3-(tert-butyl-diphenyl-silanyloxy)-3-(3-dimethoxymethyl-phenyl)-propan-1-ol

Base Information

Chemical Name:3-(tert-butyl-diphenyl-silanyloxy)-3-(3-dimethoxymethyl-phenyl)-propan-1-ol
CAS No.:467217-01-2
Molecular Formula:C₂₈H₃₆O₄Si
Molecular Weight:464.677
Hs Code.:

3-(<i>tert</i>-butyl-diphenyl-silanyloxy)-3-(3-dimethoxymethyl-phenyl)-propan-1-ol

Synonyms:3-(tert-butyl-diphenyl-silanyloxy)-3-(3-dimethoxymethyl-phenyl)-propan-1-ol

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Chemical Property of 3-(tert-butyl-diphenyl-silanyloxy)-3-(3-dimethoxymethyl-phenyl)-propan-1-ol

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Technology Process of 3-(tert-butyl-diphenyl-silanyloxy)-3-(3-dimethoxymethyl-phenyl)-propan-1-ol

There total 5 articles about 3-(tert-butyl-diphenyl-silanyloxy)-3-(3-dimethoxymethyl-phenyl)-propan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 467217-00-1
3-(tert-butyl-diphenyl-silanyloxy)-3-(3-dimethoxymethyl-phenyl)-propionic acid ethyl ester

: 467217-01-2
3-(tert-butyl-diphenyl-silanyloxy)-3-(3-dimethoxymethyl-phenyl)-propan-1-ol

Guidance literature:: With diisobutylaluminium hydride; In diethyl ether; at -60 ℃; for 1.5h;
DOI:10.1016/S0040-4039(02)01056-0

Reference yield:

: 626-19-7
Isophthalaldehyde

: 467217-01-2
3-(tert-butyl-diphenyl-silanyloxy)-3-(3-dimethoxymethyl-phenyl)-propan-1-ol

Guidance literature:: Multi-step reaction with 5 steps

1: 90 percent / NH₄NO₃ / methanol / 2 h / Heating

2: 88 percent / SiO₂; aq. H₂SO₄ / CH₂Cl₂ / 0.75 h / 20 °C

3: 79 percent / LDA / tetrahydrofuran / 0.5 h / -80 °C

4: 91 percent / imidazole / dimethylformamide / 24 h / 20 °C

5: 50 percent / DIBAL-H / diethyl ether / 1.5 h / -60 °C

With 1H-imidazole; ammonium nitrate; sulfuric acid; silica gel; diisobutylaluminium hydride; lithium diisopropyl amide; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(02)01056-0

Reference yield:

: 37832-33-0
isophthalaldehyde bis-dimethylacetal

: 467217-01-2
3-(tert-butyl-diphenyl-silanyloxy)-3-(3-dimethoxymethyl-phenyl)-propan-1-ol

Guidance literature:: Multi-step reaction with 4 steps

1: 88 percent / SiO₂; aq. H₂SO₄ / CH₂Cl₂ / 0.75 h / 20 °C

2: 79 percent / LDA / tetrahydrofuran / 0.5 h / -80 °C

3: 91 percent / imidazole / dimethylformamide / 24 h / 20 °C

4: 50 percent / DIBAL-H / diethyl ether / 1.5 h / -60 °C

With 1H-imidazole; sulfuric acid; silica gel; diisobutylaluminium hydride; lithium diisopropyl amide; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(02)01056-0