benzyl 3-(1-carbamoyl-6-morpholino-9H-pyrido[3,4-b]indol-4-yl)-2-methylphenylcarbamate

Base Information

Chemical Name:benzyl 3-(1-carbamoyl-6-morpholino-9H-pyrido[3,4-b]indol-4-yl)-2-methylphenylcarbamate
CAS No.:1352835-94-9
Molecular Formula:C₃₁H₂₉N₅O₄
Molecular Weight:535.602
Hs Code.:

Synonyms:benzyl 3-(1-carbamoyl-6-morpholino-9H-pyrido[3,4-b]indol-4-yl)-2-methylphenylcarbamate

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Chemical Property of benzyl 3-(1-carbamoyl-6-morpholino-9H-pyrido[3,4-b]indol-4-yl)-2-methylphenylcarbamate

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Technology Process of benzyl 3-(1-carbamoyl-6-morpholino-9H-pyrido[3,4-b]indol-4-yl)-2-methylphenylcarbamate

There total 11 articles about benzyl 3-(1-carbamoyl-6-morpholino-9H-pyrido[3,4-b]indol-4-yl)-2-methylphenylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1352835-92-7
4-(3-(benzyloxycarbonylamino)-2-methylphenyl)-6-morpholino-9H-pyrido[3,4-b]indole-1-carboxylic acid

: 1352835-94-9
benzyl 3-(1-carbamoyl-6-morpholino-9H-pyrido[3,4-b]indol-4-yl)-2-methylphenylcarbamate

Guidance literature:: With 4-methyl-morpholine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; ammonium chloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; for 1h;

Reference yield:

: 245117-16-2
5-(morpholyn-4-yl)-1H-indole

: 1352835-94-9
benzyl 3-(1-carbamoyl-6-morpholino-9H-pyrido[3,4-b]indol-4-yl)-2-methylphenylcarbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: 5 h / 140 °C

2.1: zinc; ammonium chloride / tetrahydrofuran; methanol / 2 h

3.1: hydrogenchloride / toluene; 1,4-dioxane / Inert atmosphere

3.2: pH ~ 10

3.3: 9 h / 125 °C

4.1: water; lithium hydroxide / tetrahydrofuran; methanol / 1.5 h

4.2: pH ~ 6

5.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; 4-methyl-morpholine; ammonium chloride / N,N-dimethyl-formamide / 1 h

With 4-methyl-morpholine; hydrogenchloride; water; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; ammonium chloride; N-ethyl-N,N-diisopropylamine; lithium hydroxide; zinc; In tetrahydrofuran; 1,4-dioxane; methanol; N,N-dimethyl-formamide; toluene;

Reference yield:

: 5192-03-0
5-amino-1H-indole

: 1352835-94-9
benzyl 3-(1-carbamoyl-6-morpholino-9H-pyrido[3,4-b]indol-4-yl)-2-methylphenylcarbamate

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium carbonate / tert-butyl alcohol / 2 h / 100 °C / Sealed tube

2.1: 5 h / 140 °C

3.1: zinc; ammonium chloride / tetrahydrofuran; methanol / 2 h

4.1: hydrogenchloride / toluene; 1,4-dioxane / Inert atmosphere

4.2: pH ~ 10

4.3: 9 h / 125 °C

5.1: water; lithium hydroxide / tetrahydrofuran; methanol / 1.5 h

5.2: pH ~ 6

6.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; 4-methyl-morpholine; ammonium chloride / N,N-dimethyl-formamide / 1 h

With 4-methyl-morpholine; hydrogenchloride; water; sodium carbonate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; ammonium chloride; N-ethyl-N,N-diisopropylamine; lithium hydroxide; zinc; In tetrahydrofuran; 1,4-dioxane; methanol; N,N-dimethyl-formamide; toluene; tert-butyl alcohol;