4-(3-amino-2-methylphenyl)-6-morpholino-9H-pyrido[3,4-b]indole-1-carboxamide

Base Information

Chemical Name:4-(3-amino-2-methylphenyl)-6-morpholino-9H-pyrido[3,4-b]indole-1-carboxamide
CAS No.:1352835-96-1
Molecular Formula:C₂₃H₂₃N₅O₂
Molecular Weight:401.468
Hs Code.:

Synonyms:4-(3-amino-2-methylphenyl)-6-morpholino-9H-pyrido[3,4-b]indole-1-carboxamide

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Chemical Property of 4-(3-amino-2-methylphenyl)-6-morpholino-9H-pyrido[3,4-b]indole-1-carboxamide

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Technology Process of 4-(3-amino-2-methylphenyl)-6-morpholino-9H-pyrido[3,4-b]indole-1-carboxamide

There total 11 articles about 4-(3-amino-2-methylphenyl)-6-morpholino-9H-pyrido[3,4-b]indole-1-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 1352835-94-9
benzyl 3-(1-carbamoyl-6-morpholino-9H-pyrido[3,4-b]indol-4-yl)-2-methylphenylcarbamate

: 1352835-96-1
4-(3-amino-2-methylphenyl)-6-morpholino-9H-pyrido[3,4-b]indole-1-carboxamide

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In tetrahydrofuran; methanol; for 1h;

Reference yield:

: 245117-16-2
5-(morpholyn-4-yl)-1H-indole

: 1352835-96-1
4-(3-amino-2-methylphenyl)-6-morpholino-9H-pyrido[3,4-b]indole-1-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: 5 h / 140 °C

2.1: zinc; ammonium chloride / tetrahydrofuran; methanol / 2 h

3.1: hydrogenchloride / toluene; 1,4-dioxane / Inert atmosphere

3.2: pH ~ 10

3.3: 9 h / 125 °C

4.1: water; lithium hydroxide / tetrahydrofuran; methanol / 1.5 h

4.2: pH ~ 6

5.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; 4-methyl-morpholine; ammonium chloride / N,N-dimethyl-formamide / 1 h

6.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; methanol / 1 h

With 4-methyl-morpholine; hydrogenchloride; water; hydrogen; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; ammonium chloride; N-ethyl-N,N-diisopropylamine; lithium hydroxide; zinc; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; N,N-dimethyl-formamide; toluene;

Reference yield:

: 5192-03-0
5-amino-1H-indole

: 1352835-96-1
4-(3-amino-2-methylphenyl)-6-morpholino-9H-pyrido[3,4-b]indole-1-carboxamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium carbonate / tert-butyl alcohol / 2 h / 100 °C / Sealed tube

2.1: 5 h / 140 °C

3.1: zinc; ammonium chloride / tetrahydrofuran; methanol / 2 h

4.1: hydrogenchloride / toluene; 1,4-dioxane / Inert atmosphere

4.2: pH ~ 10

4.3: 9 h / 125 °C

5.1: water; lithium hydroxide / tetrahydrofuran; methanol / 1.5 h

5.2: pH ~ 6

6.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; 4-methyl-morpholine; ammonium chloride / N,N-dimethyl-formamide / 1 h

7.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; methanol / 1 h

With 4-methyl-morpholine; hydrogenchloride; water; hydrogen; sodium carbonate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; ammonium chloride; N-ethyl-N,N-diisopropylamine; lithium hydroxide; zinc; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; N,N-dimethyl-formamide; toluene; tert-butyl alcohol;