Technology Process of N-[4-(1,2,3,6-tetrahydro-pyridin-4-yl)-3-trifluoromethylbenzoyl]-N?'-(carbobenzyloxy)guanidine
There total 11 articles about N-[4-(1,2,3,6-tetrahydro-pyridin-4-yl)-3-trifluoromethylbenzoyl]-N?'-(carbobenzyloxy)guanidine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
hydrogenchloride;
In
1,4-dioxane; dichloromethane;
for 2h;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -75 °C
1.2: -75 - 0 °C
1.3: 0.17 h / Cooling
2.1: potassium acetate / (diphenylphosphin)ferrocene; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 80 °C
3.1: potassium carbonate / tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane; water / 4 h / 140 °C / Sealed tube
4.1: water; potassium carbonate / methanol / 2 h / 60 °C
4.2: pH ~ 4
5.1: 2-chloro-1-methyl-pyridinium iodide / 1-methyl-pyrrolidin-2-one / 1.25 h
6.1: hydrogenchloride / 1,4-dioxane; dichloromethane / 2 h
With
hydrogenchloride; 2-chloro-1-methyl-pyridinium iodide; water; potassium acetate; potassium carbonate; lithium hexamethyldisilazane;
(diphenylphosphin)ferrocene; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one; methanol; dichloromethane; water;
3.1: Suzuki Coupling;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: potassium carbonate / tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane; water / 4 h / 140 °C / Sealed tube
2.1: water; potassium carbonate / methanol / 2 h / 60 °C
2.2: pH ~ 4
3.1: 2-chloro-1-methyl-pyridinium iodide / 1-methyl-pyrrolidin-2-one / 1.25 h
4.1: hydrogenchloride / 1,4-dioxane; dichloromethane / 2 h
With
hydrogenchloride; 2-chloro-1-methyl-pyridinium iodide; water; potassium carbonate;
tetrakis(triphenylphosphine) palladium(0);
In
1,4-dioxane; 1-methyl-pyrrolidin-2-one; methanol; dichloromethane; water;
1.1: Suzuki Coupling;
