N-{4-[1-(3-methanesulfonyl-benzoyl)-1,2,3,6-tetrahydro-pyridin-4-yl]-3-trifluoromethyl-benzoyl}-N'-(carbobenzyloxy)-guanidine

Base Information

Chemical Name:N-{4-[1-(3-methanesulfonyl-benzoyl)-1,2,3,6-tetrahydro-pyridin-4-yl]-3-trifluoromethyl-benzoyl}-N'-(carbobenzyloxy)-guanidine
CAS No.:1393368-50-7
Molecular Formula:C₃₀H₂₇F₃N₄O₆S
Molecular Weight:628.629
Hs Code.:

Synonyms:N-{4-[1-(3-methanesulfonyl-benzoyl)-1,2,3,6-tetrahydro-pyridin-4-yl]-3-trifluoromethyl-benzoyl}-N'-(carbobenzyloxy)-guanidine

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Chemical Property of N-{4-[1-(3-methanesulfonyl-benzoyl)-1,2,3,6-tetrahydro-pyridin-4-yl]-3-trifluoromethyl-benzoyl}-N'-(carbobenzyloxy)-guanidine

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Technology Process of N-{4-[1-(3-methanesulfonyl-benzoyl)-1,2,3,6-tetrahydro-pyridin-4-yl]-3-trifluoromethyl-benzoyl}-N'-(carbobenzyloxy)-guanidine

There total 14 articles about N-{4-[1-(3-methanesulfonyl-benzoyl)-1,2,3,6-tetrahydro-pyridin-4-yl]-3-trifluoromethyl-benzoyl}-N'-(carbobenzyloxy)-guanidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1204331-29-2
N-[4-(1,2,3,6-tetrahydro-pyridin-4-yl)-3-trifluoromethyl-benzoyl]-N'-(carbobenzyloxy)-guanidine

: 5345-27-7
3-(methylsulfonyl)benzoic acid

: 1393368-50-7
N-{4-[1-(3-methanesulfonyl-benzoyl)-1,2,3,6-tetrahydro-pyridin-4-yl]-3-trifluoromethyl-benzoyl}-N'-(carbobenzyloxy)-guanidine

Guidance literature:: 3-(methylsulfonyl)benzoic acid; With 1,1'-carbonyldiimidazole; In N,N-dimethyl-formamide; for 1.5h;

N-[4-(1,2,3,6-tetrahydro-pyridin-4-yl)-3-trifluoromethyl-benzoyl]-N'-(carbobenzyloxy)-guanidine; With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield: 85.0%

: 5345-27-7
3-(methylsulfonyl)benzoic acid

: 1204331-29-2
N-[4-(1,2,3,6-tetrahydro-pyridin-4-yl)-3-trifluoromethylbenzoyl]-N?'-(carbobenzyloxy)guanidine

: 1393368-50-7
C₃₀H₂₇F₃N₄O₆S

Guidance literature:: 3-(methylsulfonyl)benzoic acid; With 1,1'-carbonyldiimidazole; In N,N-dimethyl-formamide;

N-[4-(1,2,3,6-tetrahydro-pyridin-4-yl)-3-trifluoromethylbenzoyl]-N?'-(carbobenzyloxy)guanidine; With N-ethyl-N,N-diisopropylamine; at 20 ℃;
DOI:10.1021/jm300601d

Reference yield:

: 79099-07-3
N-tert-butyloxycarbonylpiperidin-4-one

: 1393368-50-7
N-{4-[1-(3-methanesulfonyl-benzoyl)-1,2,3,6-tetrahydro-pyridin-4-yl]-3-trifluoromethyl-benzoyl}-N'-(carbobenzyloxy)-guanidine

Guidance literature:: Multi-step reaction with 7 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -75 °C

1.2: -75 - 0 °C

1.3: 0.17 h / Cooling

2.1: potassium acetate / (diphenylphosphin)ferrocene; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 80 °C

3.1: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 80 °C

4.1: water; sodium hydroxide / ethanol / 2 h / Reflux

5.1: 2-chloro-1-methyl-pyridinium iodide / 1-methyl-pyrrolidin-2-one / 1.25 h

6.1: hydrogenchloride / 1,4-dioxane; dichloromethane / 2 h

7.1: 1,1'-carbonyldiimidazole / N,N-dimethyl-formamide / 1.5 h

7.2: 20 °C

With hydrogenchloride; 2-chloro-1-methyl-pyridinium iodide; water; potassium acetate; potassium carbonate; 1,1'-carbonyldiimidazole; sodium hydroxide; lithium hexamethyldisilazane; (diphenylphosphin)ferrocene; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one; ethanol; dichloromethane; N,N-dimethyl-formamide; 3.1: Suzuki Coupling;