C₁₇H₂₃N₂O₉P₂⁽¹⁺⁾

Base Information

• Chemical Name: C₁₇H₂₃N₂O₉P₂⁽¹⁺⁾
• CAS No.: 1421520-72-0
• Molecular Formula: C₁₇H₂₃N₂O₉P₂
• Molecular Weight: 461.325
• Mol file: 1421520-72-0.mol

Synonyms:C₁₇H₂₃N₂O₉P₂⁽¹⁺⁾

Chemical Property of C₁₇H₂₃N₂O₉P₂⁽¹⁺⁾

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of C₁₇H₂₃N₂O₉P₂⁽¹⁺⁾

There total 5 articles about C₁₇H₂₃N₂O₉P₂⁽¹⁺⁾ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzoic acid N-hydroxysuccinimide ester (23405-15-4) + 1-(3-amino-2-hydroxypropyl)-3-(2-hydroxy-2,2-diphosphonoethyl)pyridinium (1092514-84-5) → C17H23N2O9P2(1+) (1421520-72-0)

Guidance literature:

With sodium hydrogencarbonate; In water; N,N-dimethyl-formamide; at 20 ℃; pH=8.4; Darkness;

DOI:10.1016/j.bmcl.2012.12.051

Reference yield:

risedronic acid (105462-24-6) → C17H23N2O9P2(1+) (1421520-72-0)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydroxide / methanol; water / 18.5 h / 40 °C / pH 6.2

2: water / 3 h / 20 °C

3: sodium hydrogencarbonate / water; N,N-dimethyl-formamide / 20 °C / pH 8.4 / Darkness

With sodium hydrogencarbonate; sodium hydroxide; In methanol; water; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2012.12.051

Reference yield:

3-pyridineacetic acid hydrochloride (6419-36-9) → C17H23N2O9P2(1+) (1421520-72-0)

Guidance literature:

Multi-step reaction with 4 steps

1: phosphonic Acid; phosphorus trichloride / chlorobenzene / 8 h / 100 °C

2: sodium hydroxide / methanol; water / 18.5 h / 40 °C / pH 6.2

3: water / 3 h / 20 °C

4: sodium hydrogencarbonate / water; N,N-dimethyl-formamide / 20 °C / pH 8.4 / Darkness

With phosphonic Acid; sodium hydrogencarbonate; sodium hydroxide; phosphorus trichloride; In methanol; water; N,N-dimethyl-formamide; chlorobenzene;

DOI:10.1016/j.bmcl.2012.12.051

upstream raw materials:

risedronic acid

C₁₅H₂₇N₂O₁₀P₂⁽¹⁺⁾

benzoic acid N-hydroxysuccinimide ester

1-(3-amino-2-hydroxypropyl)-3-(2-hydroxy-2,2-diphosphonoethyl)pyridinium

Refernces