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23405-15-4

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23405-15-4 Usage

General Description

BZ-OSU is a chemical compound that exhibits selective anticancer activity by targeting certain cancer cells, while sparing normal cells. It contains a benzoyl group and an o-sulfamoylbenzoyl group, and has been found to effectively inhibit the growth of various cancer cell lines, including triple-negative breast cancer cells. BZ-OSU works through inhibition of the Akt signaling pathway, which is frequently upregulated in cancer and promotes cell survival and proliferation. It also induces apoptosis and disrupts the cell cycle progression in cancer cells. BZ-OSU shows promising potential as a targeted therapy for cancer treatment and further research is being conducted to explore its efficacy and safety in clinical applications.

Check Digit Verification of cas no

The CAS Registry Mumber 23405-15-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,3,4,0 and 5 respectively; the second part has 2 digits, 1 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 23405-15:
(7*2)+(6*3)+(5*4)+(4*0)+(3*5)+(2*1)+(1*5)=74
74 % 10 = 4
So 23405-15-4 is a valid CAS Registry Number.
InChI:InChI=1/C11H9NO4/c13-9-6-7-10(14)12(9)16-11(15)8-4-2-1-3-5-8/h1-5H,6-7H2

23405-15-4 Well-known Company Product Price

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  • Alfa Aesar

  • (H58625)  N-(Benzoyloxy)succinimide, 97%   

  • 23405-15-4

  • 1g

  • 554.0CNY

  • Detail
  • Alfa Aesar

  • (H58625)  N-(Benzoyloxy)succinimide, 97%   

  • 23405-15-4

  • 5g

  • 2218.0CNY

  • Detail

23405-15-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name (2,5-dioxopyrrolidin-1-yl) benzoate

1.2 Other means of identification

Product number -
Other names 2,5-dioxopyrrolidin-1-yl benzoate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:23405-15-4 SDS

23405-15-4Relevant articles and documents

Formation of protein charge ladders by acylation of amino groups on proteins

Colton, Ian J.,Anderson, Janelle R.,Gao, Jinming,Chapman, Robert G.,Isaacs, Lyle,Whitesides, George M.

, p. 12701 - 12709 (1997)

The values of charge and electrophoretic mobility of a protein are changed upon acylation of its α- and Lys ε-NH3+ groups. Partial acylation of the amino groups of a protein results in a set of derivatives that is often resolved by c

Preparation of N-hydroxysuccinimido esters via palladium-catalyzed carbonylation of aryl triflates and halides

Lou, Rongliang,VanAlstine, Melissa,Sun, Xufeng,Wentland, Mark P.

, p. 2477 - 2480 (2003)

N-Hydroxysuccinimido esters of aromatic carboxylic acids (a.k.a. active esters) can be made using a potentially general, one-step procedure via Pd-catalyzed carbonylation of an aryl triflate or aryl iodide with CO and N-hydroxysuccinimide. Excellent yields (up to 94%) were observed when the reaction was done in DMSO at 70°C and 1 atmosphere of CO pressure.

Eight-membered ring-containing jadomycins: Implications for non-enzymatic natural products biosynthesis

Robertson, Andrew W.,Martinez-Farina, Camilo F.,Smithen, Deborah A.,Yin, Huimin,Monro, Susan,Thompson, Alison,McFarland, Sherri A.,Syvitski, Raymond T.,Jakeman, David L.

, p. 3271 - 3275 (2015)

Jadomycin Oct (1) was isolated from Streptomyces venezuelae ISP5230 and characterized as a structurally unique eight-membered l-ornithine ring-containing jadomycin. The structure was elucidated through the semisynthetic derivatization of starting material via chemoselective acylation of the l-ornithine α-amino group using activated succinimidyl esters. Incorporation of 5-aminovaleric acid led to jadomycin AVA, a second eight-membered ring-containing jadomycin. These natural products illustrate the structural diversity permissible from a non-enzymatic step within a biosynthetic pathway and exemplifies the potential for discovery of novel scaffolds.

Development of succinimide-based inhibitors for the mitochondrial rhomboid protease PARL

Andrews, Charlotte L.,Cardozo, Joaquin M.,Chow, Alyssa S.,Crainic, Jennifer A.,Parsons, William H.,Rutland, Nicholas T.,Sheehan, Brendan K.

supporting information, (2021/08/04)

While the biochemistry of rhomboid proteases has been extensively studied since their discovery two decades ago, efforts to define the physiological roles of these enzymes are ongoing and would benefit from chemical probes that can be used to manipulate the functions of these proteins in their native settings. Here, we describe the use of activity-based protein profiling (ABPP) technology to conduct a targeted screen for small-molecule inhibitors of the mitochondrial rhomboid protease PARL, which plays a critical role in regulating mitophagy and cell death. We synthesized a series of succinimide-containing sulfonyl esters and sulfonamides and discovered that these compounds serve as inhibitors of PARL with the most potent sulfonamides having submicromolar affinity for the enzyme. A counterscreen against the bacterial rhomboid protease GlpG demonstrates that several of these compounds display selectivity for PARL over GlpG by as much as two orders of magnitude. Both the sulfonyl ester and sulfonamide scaffolds exhibit reversible binding and are able to engage PARL in mammalian cells. Collectively, our findings provide encouraging precedent for the development of PARL-selective inhibitors and establish N-[(arylsulfonyl)oxy]succinimides and N-arylsulfonylsuccinimides as new molecular scaffolds for inhibiting members of the rhomboid protease family.

CHEMOSELECTIVE SENSITIVITY BOOSTER FOR TAGGING A PEPTIDE, PEPTIDE CONJUGATE, OR SIMILAR REACTIVE MOLECULE

-

Page/Page column 39, (2020/12/29)

The invention pertains to chemoselective sensitivity booster for tagging a peptide, peptide conjugate, or similar reactive molecule for analysis of a peptide, protein, antibody, protein bioconjugate, antibody bioconjugate, and similar analytes. The sensitivity booster comprises of sp2 or sp3 nitrogen centers in combination with hydrophobic carbon chains linked with an electrophile or nucleophile for attachment with a peptide, peptide conjugate, or molecules with similar reactivity.

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