C₄₇H₅₂N₄O₁₄

Base Information

• Chemical Name: C₄₇H₅₂N₄O₁₄
• CAS No.: 1146622-42-5
• Molecular Formula: C₄₇H₅₂N₄O₁₄
• Molecular Weight: 896.948
• Mol file: 1146622-42-5.mol

Synonyms:C₄₇H₅₂N₄O₁₄

Chemical Property of C₄₇H₅₂N₄O₁₄

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₄₇H₅₂N₄O₁₄

There total 9 articles about C₄₇H₅₂N₄O₁₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C53H66N4O14Si (1146622-40-3) → C47H52N4O14 (1146622-42-5)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 0.166667h;

DOI:10.1039/c0cc02028a

Reference yield:

5'-O-(4-4'-dimethoxytrityl)thymidine (40615-39-2) → C47H52N4O14 (1146622-42-5)

Guidance literature:

Multi-step reaction with 6 steps

1: 1H-imidazole / N,N-dimethyl-formamide / 20 °C

2: trifluoroacetic acid / methanol; dichloromethane / 4 h / 0 °C

3: pyridine / 20 °C

4: caesium carbonate / N,N-dimethyl-formamide / 0.5 h / 20 °C

5: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 0.27 h

6: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.17 h / 20 °C

With pyridine; 1H-imidazole; tetrabutyl ammonium fluoride; caesium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1039/c0cc02028a

Reference yield:

thymidine (50-89-5,28854-96-8,3545-96-8,50-88-4) → C47H52N4O14 (1146622-42-5)

Guidance literature:

Multi-step reaction with 7 steps

1: pyridine / 20 °C

2: 1H-imidazole / N,N-dimethyl-formamide / 20 °C

3: trifluoroacetic acid / methanol; dichloromethane / 4 h / 0 °C

4: pyridine / 20 °C

5: caesium carbonate / N,N-dimethyl-formamide / 0.5 h / 20 °C

6: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 0.27 h

7: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.17 h / 20 °C

With pyridine; 1H-imidazole; tetrabutyl ammonium fluoride; caesium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1039/c0cc02028a

upstream raw materials:

C₂₀H₃₃BrN₂O₆Si

C₅₃H₆₆N₄O₁₄Si

4,4'-dimethoxytrityl chloride

3'-O-acetyl-5'-O-[bis(4-methoxyphenyl)(phenyl)methyl]-2'-deoxy-3,4-dihydrothymidine

Downstream raw materials:

C₅₆H₆₉N₆O₁₅P