4-[(1E)-2-(1H-benzimidazol-2-yl)ethenyl]-2,5-dimethoxybenzaldehyde

Base Information

• Chemical Name: 4-[(1E)-2-(1H-benzimidazol-2-yl)ethenyl]-2,5-dimethoxybenzaldehyde
• CAS No.: 1616390-03-4
• Molecular Formula: C₁₈H₁₆N₂O₃
• Molecular Weight: 308.337
• Mol file: 1616390-03-4.mol

Synonyms:4-[(1E)-2-(1H-benzimidazol-2-yl)ethenyl]-2,5-dimethoxybenzaldehyde

Chemical Property of 4-[(1E)-2-(1H-benzimidazol-2-yl)ethenyl]-2,5-dimethoxybenzaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-[(1E)-2-(1H-benzimidazol-2-yl)ethenyl]-2,5-dimethoxybenzaldehyde

There total 3 articles about 4-[(1E)-2-(1H-benzimidazol-2-yl)ethenyl]-2,5-dimethoxybenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.3%

2-Methyl-1H-benzimidazole (615-15-6) + 2,5-dimethoxyterephthalaldehyde (7310-97-6) → 4-[(1E)-2-(1H-benzimidazol-2-yl)ethenyl]-2,5-dimethoxybenzaldehyde (1616390-03-4)

Guidance literature:

With acetic anhydride; acetic acid; for 6h; Reflux;

DOI:10.1039/c4nj00360h

Reference yield:

1,4-dimethoxybezene (150-78-7) → 4-[(1E)-2-(1H-benzimidazol-2-yl)ethenyl]-2,5-dimethoxybenzaldehyde (1616390-03-4)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrogen bromide

2: hexamethylenetetramine / chloroform

3: acetic anhydride; acetic acid / 6 h / Reflux

With hexamethylenetetramine; hydrogen bromide; acetic anhydride; acetic acid; In chloroform; 2: |Sommelet Aldehyde Synthesis;

DOI:10.1039/c4nj00360h

Reference yield:

1,4-bis(bromomethyl)-2,5-dimethoxybenzene (50874-27-6) → 4-[(1E)-2-(1H-benzimidazol-2-yl)ethenyl]-2,5-dimethoxybenzaldehyde (1616390-03-4)

Guidance literature:

Multi-step reaction with 2 steps

1: hexamethylenetetramine

2: acetic anhydride; acetic acid

With hexamethylenetetramine; acetic anhydride; acetic acid;

DOI:10.1016/j.tet.2017.03.075

upstream raw materials:

1,4-dimethoxybezene

2-Methyl-1H-benzimidazole

2,5-dimethoxyterephthalaldehyde

1,4-bis(bromomethyl)-2,5-dimethoxybenzene

Downstream raw materials:

2-[(1E)-2-[2,5-dimethoxy-4-[(1E)-2-(4,6-dimethyl-1,3,5-triazin-2-yl)ethenyl]phenyl]ethenyl]-1H-benzimidazole