[2-(tert-butyldimethylsilyloxy)-6-(4-chlorobutyl)cyclohexen-1-yl]-1-carbonitrile

Base Information

• Chemical Name: [2-(tert-butyldimethylsilyloxy)-6-(4-chlorobutyl)cyclohexen-1-yl]-1-carbonitrile
• CAS No.: 252989-00-7
• Molecular Formula: C₁₇H₃₀ClNOSi
• Molecular Weight: 327.97
• Mol file: 252989-00-7.mol

Synonyms:[2-(tert-butyldimethylsilyloxy)-6-(4-chlorobutyl)cyclohexen-1-yl]-1-carbonitrile

Chemical Property of [2-(tert-butyldimethylsilyloxy)-6-(4-chlorobutyl)cyclohexen-1-yl]-1-carbonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [2-(tert-butyldimethylsilyloxy)-6-(4-chlorobutyl)cyclohexen-1-yl]-1-carbonitrile

There total 3 articles about [2-(tert-butyldimethylsilyloxy)-6-(4-chlorobutyl)cyclohexen-1-yl]-1-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

4-chlorobutyl bromide (6940-78-9) + 6-oxocyclohexene-1-carbonitrile (91624-93-0) + tert-butyldimethylsilyl chloride (18162-48-6) → [2-(tert-butyldimethylsilyloxy)-6-(4-chlorobutyl)cyclohexen-1-yl]-1-carbonitrile (252989-00-7)

Guidance literature:

4-chlorobutyl bromide; With magnesium; In tetrahydrofuran; at 0 - 20 ℃; Irradiation;

6-oxocyclohexene-1-carbonitrile; In tetrahydrofuran; at -78 - 20 ℃;

tert-butyldimethylsilyl chloride; In tetrahydrofuran; at 20 ℃; for 15h;

DOI:10.1016/S0040-4020(02)01615-0

Reference yield: 66.0%

6-oxocyclohexene-1-carbonitrile (91624-93-0) + 4-chlorobutylmagnesium bromide (86517-04-6) + tert-butyldimethylsilyl chloride (18162-48-6) → [2-(tert-butyldimethylsilyloxy)-6-(4-chlorobutyl)cyclohexen-1-yl]-1-carbonitrile (252989-00-7)

Guidance literature:

6-oxocyclohexene-1-carbonitrile; 4-chlorobutylmagnesium bromide; In tetrahydrofuran; at -78 ℃;

tert-butyldimethylsilyl chloride; In tetrahydrofuran; Further stages.;

DOI:10.1021/ol990854s

Reference yield: 14.0%

4-chlorobutyl bromide (6940-78-9) + 6-oxocyclohexene-1-carbonitrile (91624-93-0) + tert-butyldimethylsilyl chloride (18162-48-6) → [2-(tert-butyldimethylsilyloxy)-6-(4-chlorobutyl)cyclohexen-1-yl]-1-carbonitrile (252989-00-7) + C30H52N2O2Si2

Guidance literature:

4-chlorobutyl bromide; With magnesium; In tetrahydrofuran;

6-oxocyclohexene-1-carbonitrile; In tetrahydrofuran; at -78 - 20 ℃;

tert-butyldimethylsilyl chloride; In tetrahydrofuran; at 20 ℃; for 15h;

DOI:10.1016/S0040-4020(02)01615-0

upstream raw materials:

4-chlorobutyl bromide

6-oxocyclohexene-1-carbonitrile

tert-butyldimethylsilyl chloride

4-chlorobutylmagnesium bromide

Downstream raw materials:

(1R,2R,6S)-2-(4-Chloro-butyl)-6-hydroxy-cyclohexanecarbonitrile

[2-(tert-butyldimethylsilyloxy)-6-(5-chloro-2-methylpent-2-yl)cyclohexen-1-yl]carbonitrile