tert-butyl-3-((1-benzyl-1H-benzo[d]imidazol-2-yl)methylcarbamoyl)-3,4-dihydroiso-quinoline-2(1H)-carboxylate

Base Information

Chemical Name:tert-butyl-3-((1-benzyl-1H-benzo[d]imidazol-2-yl)methylcarbamoyl)-3,4-dihydroiso-quinoline-2(1H)-carboxylate
CAS No.:873530-14-4
Molecular Formula:C₃₀H₃₂N₄O₃
Molecular Weight:496.609
Hs Code.:

Synonyms:tert-butyl-3-((1-benzyl-1H-benzo[d]imidazol-2-yl)methylcarbamoyl)-3,4-dihydroiso-quinoline-2(1H)-carboxylate

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Chemical Property of tert-butyl-3-((1-benzyl-1H-benzo[d]imidazol-2-yl)methylcarbamoyl)-3,4-dihydroiso-quinoline-2(1H)-carboxylate

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Technology Process of tert-butyl-3-((1-benzyl-1H-benzo[d]imidazol-2-yl)methylcarbamoyl)-3,4-dihydroiso-quinoline-2(1H)-carboxylate

There total 5 articles about tert-butyl-3-((1-benzyl-1H-benzo[d]imidazol-2-yl)methylcarbamoyl)-3,4-dihydroiso-quinoline-2(1H)-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 100-39-0
benzyl bromide

: 403652-15-3
Boc-Tic-NH-CH₂-Bid

: 873530-14-4
tert-butyl-3-((1-benzyl-1H-benzo[d]imidazol-2-yl)methylcarbamoyl)-3,4-dihydroiso-quinoline-2(1H)-carboxylate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 24h;
DOI:10.1021/jm058259l

Reference yield:

: 5805-57-2
2-Aminomethylbenzimidazole

: 873530-14-4
tert-butyl-3-((1-benzyl-1H-benzo[d]imidazol-2-yl)methylcarbamoyl)-3,4-dihydroiso-quinoline-2(1H)-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: WSC; HOBt

2: 89 percent / K₂CO₃ / dimethylformamide / 24 h / 20 °C

With potassium carbonate; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In N,N-dimethyl-formamide;
DOI:10.1021/jm058259l

Reference yield:

: 95-54-5
1,2-diamino-benzene

: 873530-14-4
tert-butyl-3-((1-benzyl-1H-benzo[d]imidazol-2-yl)methylcarbamoyl)-3,4-dihydroiso-quinoline-2(1H)-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: IBCF

2: CH₃COOH / 1 h / 65 °C

3: TFA

4: WSC; HOBt

5: 89 percent / K₂CO₃ / dimethylformamide / 24 h / 20 °C

With potassium carbonate; benzotriazol-1-ol; acetic acid; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; trifluoroacetic acid; isobutyl chloroformate; In N,N-dimethyl-formamide;
DOI:10.1021/jm058259l