7-amino-6-cyano-5-(4-methoxyphenyl)-1,2,3,4,5,8-hexahydropyrido[2,3-d]pyrimidine-2,4-dione

Base Information

• Chemical Name: 7-amino-6-cyano-5-(4-methoxyphenyl)-1,2,3,4,5,8-hexahydropyrido[2,3-d]pyrimidine-2,4-dione
• CAS No.: 887031-52-9
• Molecular Formula: C₁₅H₁₃N₅O₃
• Molecular Weight: 311.3

Synonyms:7-amino-6-cyano-5-(4-methoxyphenyl)-1,2,3,4,5,8-hexahydropyrido[2,3-d]pyrimidine-2,4-dione

Chemical Property of 7-amino-6-cyano-5-(4-methoxyphenyl)-1,2,3,4,5,8-hexahydropyrido[2,3-d]pyrimidine-2,4-dione

Chemical Property:

Purity/Quality:

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Technology Process of 7-amino-6-cyano-5-(4-methoxyphenyl)-1,2,3,4,5,8-hexahydropyrido[2,3-d]pyrimidine-2,4-dione

There total 2 articles about 7-amino-6-cyano-5-(4-methoxyphenyl)-1,2,3,4,5,8-hexahydropyrido[2,3-d]pyrimidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

4-Amino-2,6-dihydroxypyrimidine (873-83-6) + 4-methoxy-benzaldehyde (123-11-5) + malononitrile (109-77-3) → 7-amino-6-cyano-5-(4-methoxyphenyl)-1,2,3,4,5,8-hexahydropyrido[2,3-d]pyrimidine-2,4-dione (887031-52-9)

Guidance literature:

In water; for 2h; Heating; Green chemistry;

DOI:10.1007/s13738-020-02073-z

Reference yield: 84.0%

BARBITURIC ACID (67-52-7,944357-77-1) + 4-methoxy-benzaldehyde (123-11-5) + malononitrile (109-77-3) → 7-amino-6-cyano-5-(4-methoxyphenyl)-1,2,3,4,5,8-hexahydropyrido[2,3-d]pyrimidine-2,4-dione (887031-52-9)

Guidance literature:

With ammonium acetate; In methanol; Reflux;

Reference yield: 73.0%

7-amino-6-cyano-5-(4-methoxyphenyl)-1,2,3,4,5,8-hexahydropyrido[2,3-d]pyrimidine-2,4-dione (887031-52-9) + ethyl 2-cyanoacetate (105-56-6) → 6-amino-7-cyano-5-(4-methoxyphenyl)-1,2,3,4,5,8,9,10-octahydropyrimido[4,5-b][1,8]naphthyridine-2,4,8-trione (1261069-48-0) + 6,8-diamino-7-ethoxycarbonyl-5-(4-methoxyphenyl)-1,2,3,4,5,10-hexahydropyrimido[4,5-b][1,8]naphthyridine-2,4-dione (1261069-44-6)

Guidance literature:

With piperidine; In N,N-dimethyl-formamide; Reflux;

upstream raw materials:

BARBITURIC ACID

4-methoxy-benzaldehyde

malononitrile

4-Amino-2,6-dihydroxypyrimidine

Downstream raw materials:

5-amino-6-(4-methoxyphenyl)-1,2,3,4,5,7,8,9,10,12-decahydrodipyrimido[4,5-b:5',4'-g][1,8]naphthyridine-2,4,7,9-tetraone

7-aceto-6-amino-5-(4-methoxyphenyl)-1,2,3,4,5,8,9,10-octahydropyrimido[4,5-b][1,8]naphthyridine-2,4,8-trione

6-amino-7-ethoxycarbonyl-8-methyl-5-(4-methoxyphenyl)-1,2,3,4,5,10-hexahydropyrimido[4,5-b][1,8]naphthyridine-2,4-dione

C₂₃H₂₃N₅O₄

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