2'-bromo-4',5'-dimethoxybenzoic acid N-methyl-N-(2-isopropoxy-3-methoxy-5-naphthyl)amide

Base Information

• Chemical Name: 2'-bromo-4',5'-dimethoxybenzoic acid N-methyl-N-(2-isopropoxy-3-methoxy-5-naphthyl)amide
• CAS No.: 123719-70-0
• Molecular Formula: C₂₄H₂₆BrNO₅
• Molecular Weight: 488.378
• Mol file: 123719-70-0.mol

Synonyms:2'-bromo-4',5'-dimethoxybenzoic acid N-methyl-N-(2-isopropoxy-3-methoxy-5-naphthyl)amide

Chemical Property of 2'-bromo-4',5'-dimethoxybenzoic acid N-methyl-N-(2-isopropoxy-3-methoxy-5-naphthyl)amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2'-bromo-4',5'-dimethoxybenzoic acid N-methyl-N-(2-isopropoxy-3-methoxy-5-naphthyl)amide

There total 7 articles about 2'-bromo-4',5'-dimethoxybenzoic acid N-methyl-N-(2-isopropoxy-3-methoxy-5-naphthyl)amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2'-bromo-4',5'-dimethoxybenzoic acid 2-isopropoxy-3-methoxy-5-naphthylamide (123719-69-7) + dimethyl sulfate (77-78-1) → 2'-bromo-4',5'-dimethoxybenzoic acid N-methyl-N-(2-isopropoxy-3-methoxy-5-naphthyl)amide (123719-70-0)

Guidance literature:

With sodium hydroxide; In water; acetone; for 2h; Heating;

Reference yield:

2-bromo-4,5-dimethoxybenzaldehyde (5392-10-9) → 2'-bromo-4',5'-dimethoxybenzoic acid N-methyl-N-(2-isopropoxy-3-methoxy-5-naphthyl)amide (123719-70-0)

Guidance literature:

Multi-step reaction with 4 steps

1: 74 percent / KMnO₄ / H₂O; acetone / 1 h / Heating

2: SOCl₂ / CHCl₃ / 1 h / Heating

3: 81 percent / triethylamine, dimethylpropylamine / CH₂Cl₂ / 1 h / 0 °C

4: 90 percent / NaOH / H₂O; acetone / 2 h / Heating

With sodium hydroxide; potassium permanganate; thionyl chloride; N,N-dimethylaminopropane; triethylamine; In dichloromethane; chloroform; water; acetone;

Reference yield:

2-hydroxy-3-methoxy-5-nitronaphthalene (24309-45-3) → 2'-bromo-4',5'-dimethoxybenzoic acid N-methyl-N-(2-isopropoxy-3-methoxy-5-naphthyl)amide (123719-70-0)

Guidance literature:

Multi-step reaction with 4 steps

3: 81 percent / triethylamine, dimethylpropylamine / CH₂Cl₂ / 1 h / 0 °C

4: 90 percent / NaOH / H₂O; acetone / 2 h / Heating

With sodium hydroxide; N,N-dimethylaminopropane; triethylamine; In dichloromethane; water; acetone;

upstream raw materials:

2'-bromo-4',5'-dimethoxybenzoic acid 2-isopropoxy-3-methoxy-5-naphthylamide

dimethyl sulfate

2-bromo-4,5-dimethoxybenzaldehyde

2-bromo-4,5-dimethoxybenzoic acid

Downstream raw materials:

2-isopropoxy-3,8,9-trimethoxy-5-methyl-6-oxo-5,6-dihydrobenzophenanthridine