2'-bromo-4',5'-dimethoxybenzoic acid 2-isopropoxy-3-methoxy-5-naphthylamide

Base Information

• Chemical Name: 2'-bromo-4',5'-dimethoxybenzoic acid 2-isopropoxy-3-methoxy-5-naphthylamide
• CAS No.: 123719-69-7
• Molecular Formula: C₂₃H₂₄BrNO₅
• Molecular Weight: 474.351
• Mol file: 123719-69-7.mol

Synonyms:2'-bromo-4',5'-dimethoxybenzoic acid 2-isopropoxy-3-methoxy-5-naphthylamide

Chemical Property of 2'-bromo-4',5'-dimethoxybenzoic acid 2-isopropoxy-3-methoxy-5-naphthylamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2'-bromo-4',5'-dimethoxybenzoic acid 2-isopropoxy-3-methoxy-5-naphthylamide

There total 5 articles about 2'-bromo-4',5'-dimethoxybenzoic acid 2-isopropoxy-3-methoxy-5-naphthylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

5-amino-2-isopropoxy-3-methoxynaphthalene (52259-69-5) + 2-bromo-4,5-dimethoxybenzoyl chloride (55171-61-4) → 2'-bromo-4',5'-dimethoxybenzoic acid 2-isopropoxy-3-methoxy-5-naphthylamide (123719-69-7)

Guidance literature:

With N,N-dimethylaminopropane; triethylamine; In dichloromethane; at 0 ℃; for 1h;

Reference yield:

2-bromo-4,5-dimethoxybenzaldehyde (5392-10-9) → 2'-bromo-4',5'-dimethoxybenzoic acid 2-isopropoxy-3-methoxy-5-naphthylamide (123719-69-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 74 percent / KMnO₄ / H₂O; acetone / 1 h / Heating

2: SOCl₂ / CHCl₃ / 1 h / Heating

3: 81 percent / triethylamine, dimethylpropylamine / CH₂Cl₂ / 1 h / 0 °C

With potassium permanganate; thionyl chloride; N,N-dimethylaminopropane; triethylamine; In dichloromethane; chloroform; water; acetone;

Reference yield:

2-bromo-4,5-dimethoxybenzoic acid (6286-46-0) → 2'-bromo-4',5'-dimethoxybenzoic acid 2-isopropoxy-3-methoxy-5-naphthylamide (123719-69-7)

Guidance literature:

Multi-step reaction with 2 steps

1: SOCl₂ / CHCl₃ / 1 h / Heating

2: 81 percent / triethylamine, dimethylpropylamine / CH₂Cl₂ / 1 h / 0 °C

With thionyl chloride; N,N-dimethylaminopropane; triethylamine; In dichloromethane; chloroform;

upstream raw materials:

5-amino-2-isopropoxy-3-methoxynaphthalene

2-bromo-4,5-dimethoxybenzoyl chloride

2-bromo-4,5-dimethoxybenzaldehyde

2-bromo-4,5-dimethoxybenzoic acid

Downstream raw materials:

2'-bromo-4',5'-dimethoxybenzoic acid N-methyl-N-(2-isopropoxy-3-methoxy-5-naphthyl)amide

fagaronine