(E)-3-[2-n-butyl-1-{(2-chlorophenyl)methyl}-1H-imidazol-5-yl]-2-(2-thienyl)methyl-2-propenol

Base Information

Chemical Name:(E)-3-[2-n-butyl-1-{(2-chlorophenyl)methyl}-1H-imidazol-5-yl]-2-(2-thienyl)methyl-2-propenol
CAS No.:133486-21-2
Molecular Formula:C₂₂H₂₅ClN₂OS
Molecular Weight:400.972
Hs Code.:

Synonyms:(E)-3-[2-n-butyl-1-{(2-chlorophenyl)methyl}-1H-imidazol-5-yl]-2-(2-thienyl)methyl-2-propenol

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Chemical Property of (E)-3-[2-n-butyl-1-{(2-chlorophenyl)methyl}-1H-imidazol-5-yl]-2-(2-thienyl)methyl-2-propenol

Chemical Property:

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Technology Process of (E)-3-[2-n-butyl-1-{(2-chlorophenyl)methyl}-1H-imidazol-5-yl]-2-(2-thienyl)methyl-2-propenol

There total 8 articles about (E)-3-[2-n-butyl-1-{(2-chlorophenyl)methyl}-1H-imidazol-5-yl]-2-(2-thienyl)methyl-2-propenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 133485-47-9
methyl (E)-3-<2-butyl-1-<(2-chlorophenyl)methyl>imidazol-5-yl>-2-<(2-thienyl)methyl>-2-propenoate

: 133486-21-2
(E)-3-[2-n-butyl-1-{(2-chlorophenyl)methyl}-1H-imidazol-5-yl]-2-(2-thienyl)methyl-2-propenol

Guidance literature:: With hydrogenchloride; diisobutylaluminium hydride; In tetrahydrofuran; methanol; water; acetic acid;

Reference yield:

: 16862-05-8
methyl 3-(2-thienyl)propanoate

: 133486-21-2
(E)-3-[2-n-butyl-1-{(2-chlorophenyl)methyl}-1H-imidazol-5-yl]-2-(2-thienyl)methyl-2-propenol

Guidance literature:: Multi-step reaction with 4 steps

1: n-butyllithium; diisopropylamine / tetrahydrofuran; ethyl acetate; toluene

2: dmap; acetic anhydride / dichloromethane; water

3: toluene

4: hydrogenchloride; diisobutylaluminium hydride / tetrahydrofuran; methanol; water; acetic acid

With hydrogenchloride; dmap; n-butyllithium; acetic anhydride; diisobutylaluminium hydride; diisopropylamine; In tetrahydrofuran; methanol; dichloromethane; water; acetic acid; ethyl acetate; toluene;

Reference yield:

: 17849-38-6
2-Chlorobenzyl alcohol

: 133486-21-2
(E)-3-[2-n-butyl-1-{(2-chlorophenyl)methyl}-1H-imidazol-5-yl]-2-(2-thienyl)methyl-2-propenol

Guidance literature:: Multi-step reaction with 6 steps

1: sodium hydroxide; trifluoromethylsulfonic anhydride / methanol; dichloromethane

2: manganese dioxide / hexane; dichloromethane; toluene

3: n-butyllithium; diisopropylamine / tetrahydrofuran; ethyl acetate; toluene

4: dmap; acetic anhydride / dichloromethane; water

5: toluene

6: hydrogenchloride; diisobutylaluminium hydride / tetrahydrofuran; methanol; water; acetic acid

With hydrogenchloride; dmap; sodium hydroxide; n-butyllithium; manganese dioxide; trifluoromethylsulfonic anhydride; acetic anhydride; diisobutylaluminium hydride; diisopropylamine; In tetrahydrofuran; methanol; hexane; dichloromethane; water; acetic acid; ethyl acetate; toluene;