2-[2-(2-bromo-5-fluorophenoxy)ethoxy]-5-(1H-tetrazol-5-yl)pyrazine

Base Information

• Chemical Name: 2-[2-(2-bromo-5-fluorophenoxy)ethoxy]-5-(1H-tetrazol-5-yl)pyrazine
• CAS No.: 1073319-72-8
• Molecular Formula: C₁₃H₁₀BrFN₆O₂
• Molecular Weight: 381.164
• Mol file: 1073319-72-8.mol

Synonyms:2-[2-(2-bromo-5-fluorophenoxy)ethoxy]-5-(1H-tetrazol-5-yl)pyrazine

Chemical Property of 2-[2-(2-bromo-5-fluorophenoxy)ethoxy]-5-(1H-tetrazol-5-yl)pyrazine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[2-(2-bromo-5-fluorophenoxy)ethoxy]-5-(1H-tetrazol-5-yl)pyrazine

There total 5 articles about 2-[2-(2-bromo-5-fluorophenoxy)ethoxy]-5-(1H-tetrazol-5-yl)pyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-[2-(2-bromo-5-fluorophenoxy)ethoxy]pyrazine-2-carbonitrile (1073319-71-7) → 2-[2-(2-bromo-5-fluorophenoxy)ethoxy]-5-(1H-tetrazol-5-yl)pyrazine (1073319-72-8)

Guidance literature:

With sodium azide; ammonium chloride; In N,N-dimethyl-formamide; at 100 ℃; for 2h;

Reference yield:

methyl 5-[2-(2-bromo-5-fluorophenoxy)ethoxy]pyrazine-2-carboxylate (1073319-69-3) → 2-[2-(2-bromo-5-fluorophenoxy)ethoxy]-5-(1H-tetrazol-5-yl)pyrazine (1073319-72-8)

Guidance literature:

Multi-step reaction with 3 steps

1: ammonia / tetrahydrofuran; methanol / 5 h / 125 °C

2: N-ethyl-N,N-diisopropylamine; trifluoroacetic anhydride / dichloromethane / -78 - 0 °C

3: sodium azide; ammonium chloride / N,N-dimethyl-formamide / 2 h / 100 °C

With sodium azide; ammonia; ammonium chloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic anhydride; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

5-[2-(2-bromo-5-fluorophenoxy)ethoxy]pyrazine-2-carboxamide (1073319-70-6) → 2-[2-(2-bromo-5-fluorophenoxy)ethoxy]-5-(1H-tetrazol-5-yl)pyrazine (1073319-72-8)

Guidance literature:

Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine; trifluoroacetic anhydride / dichloromethane / -78 - 0 °C

2: sodium azide; ammonium chloride / N,N-dimethyl-formamide / 2 h / 100 °C

With sodium azide; ammonium chloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic anhydride; In dichloromethane; N,N-dimethyl-formamide;

upstream raw materials:

5-[2-(2-bromo-5-fluorophenoxy)ethoxy]pyrazine-2-carbonitrile

2-(2-bromo-5-fluorophenoxy)ethanol

methyl 5-[2-(2-bromo-5-fluorophenoxy)ethoxy]pyrazine-2-carboxylate

5-[2-(2-bromo-5-fluorophenoxy)ethoxy]pyrazine-2-carboxamide

Downstream raw materials:

ethyl (5-{5-[2-(2-bromo-5-fluorophenoxy)ethoxy]pyrazin-2-yl}-1H-tetrazol-1-yl)acetate

ethyl (5-{5-[2-(2-bromo-5-fluorophenoxy)ethoxy]pyrazin-2-yl}-2H-tetrazol-2-yl)acetate

(5-{5-[2-(2-bromo-5-fluorophenoxy)ethoxy]pyrazin-2-yl}-2H-tetrazol-2-yl)acetic acid