ethyl (5-{5-[2-(2-bromo-5-fluorophenoxy)ethoxy]pyrazin-2-yl}-2H-tetrazol-2-yl)acetate

Base Information

• Chemical Name: ethyl (5-{5-[2-(2-bromo-5-fluorophenoxy)ethoxy]pyrazin-2-yl}-2H-tetrazol-2-yl)acetate
• CAS No.: 1073319-73-9
• Molecular Formula: C₁₇H₁₆BrFN₆O₄
• Molecular Weight: 467.254
• Mol file: 1073319-73-9.mol

Synonyms:ethyl (5-{5-[2-(2-bromo-5-fluorophenoxy)ethoxy]pyrazin-2-yl}-2H-tetrazol-2-yl)acetate

Chemical Property of ethyl (5-{5-[2-(2-bromo-5-fluorophenoxy)ethoxy]pyrazin-2-yl}-2H-tetrazol-2-yl)acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl (5-{5-[2-(2-bromo-5-fluorophenoxy)ethoxy]pyrazin-2-yl}-2H-tetrazol-2-yl)acetate

There total 5 articles about ethyl (5-{5-[2-(2-bromo-5-fluorophenoxy)ethoxy]pyrazin-2-yl}-2H-tetrazol-2-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-[2-(2-bromo-5-fluorophenoxy)ethoxy]-5-(1H-tetrazol-5-yl)pyrazine (1073319-72-8) + ethyl bromoacetate (105-36-2) → ethyl (5-{5-[2-(2-bromo-5-fluorophenoxy)ethoxy]pyrazin-2-yl}-1H-tetrazol-1-yl)acetate (1073319-74-0) + ethyl (5-{5-[2-(2-bromo-5-fluorophenoxy)ethoxy]pyrazin-2-yl}-2H-tetrazol-2-yl)acetate (1073319-73-9)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; at 90 ℃; for 1h;

Reference yield:

methyl 5-[2-(2-bromo-5-fluorophenoxy)ethoxy]pyrazine-2-carboxylate (1073319-69-3) → ethyl (5-{5-[2-(2-bromo-5-fluorophenoxy)ethoxy]pyrazin-2-yl}-2H-tetrazol-2-yl)acetate (1073319-73-9)

Guidance literature:

Multi-step reaction with 4 steps

1: ammonia / tetrahydrofuran; methanol / 5 h / 125 °C

2: N-ethyl-N,N-diisopropylamine; trifluoroacetic anhydride / dichloromethane / -78 - 0 °C

3: sodium azide; ammonium chloride / N,N-dimethyl-formamide / 2 h / 100 °C

4: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 1 h / 90 °C

With sodium azide; ammonia; ammonium chloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic anhydride; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

2-(2-bromo-5-fluorophenoxy)ethanol (1073318-98-5) → ethyl (5-{5-[2-(2-bromo-5-fluorophenoxy)ethoxy]pyrazin-2-yl}-2H-tetrazol-2-yl)acetate (1073319-73-9)

Guidance literature:

Multi-step reaction with 5 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.33 - 0.5 h / -78 - 20 °C

1.2: 1 h / -78 - 20 °C

2.1: ammonia / tetrahydrofuran; methanol / 5 h / 125 °C

3.1: N-ethyl-N,N-diisopropylamine; trifluoroacetic anhydride / dichloromethane / -78 - 0 °C

4.1: sodium azide; ammonium chloride / N,N-dimethyl-formamide / 2 h / 100 °C

5.1: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 1 h / 90 °C

With sodium azide; ammonia; sodium hydride; ammonium chloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic anhydride; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;

upstream raw materials:

2-[2-(2-bromo-5-fluorophenoxy)ethoxy]-5-(1H-tetrazol-5-yl)pyrazine

ethyl bromoacetate

2-(2-bromo-5-fluorophenoxy)ethanol

methyl 5-[2-(2-bromo-5-fluorophenoxy)ethoxy]pyrazine-2-carboxylate

Downstream raw materials:

(5-{5-[2-(2-bromo-5-fluorophenoxy)ethoxy]pyrazin-2-yl}-2H-tetrazol-2-yl)acetic acid