ethyl (5-{5-[2-(2-bromo-5-fluorophenoxy)ethoxy]pyrazin-2-yl}-1H-tetrazol-1-yl)acetate

Base Information

Chemical Name:ethyl (5-{5-[2-(2-bromo-5-fluorophenoxy)ethoxy]pyrazin-2-yl}-1H-tetrazol-1-yl)acetate
CAS No.:1073319-74-0
Molecular Formula:C₁₇H₁₆BrFN₆O₄
Molecular Weight:467.254
Hs Code.:

Synonyms:ethyl (5-{5-[2-(2-bromo-5-fluorophenoxy)ethoxy]pyrazin-2-yl}-1H-tetrazol-1-yl)acetate

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Chemical Property of ethyl (5-{5-[2-(2-bromo-5-fluorophenoxy)ethoxy]pyrazin-2-yl}-1H-tetrazol-1-yl)acetate

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Technology Process of ethyl (5-{5-[2-(2-bromo-5-fluorophenoxy)ethoxy]pyrazin-2-yl}-1H-tetrazol-1-yl)acetate

There total 5 articles about ethyl (5-{5-[2-(2-bromo-5-fluorophenoxy)ethoxy]pyrazin-2-yl}-1H-tetrazol-1-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1073319-72-8
2-[2-(2-bromo-5-fluorophenoxy)ethoxy]-5-(1H-tetrazol-5-yl)pyrazine

: 105-36-2
ethyl bromoacetate

: 1073319-74-0
ethyl (5-{5-[2-(2-bromo-5-fluorophenoxy)ethoxy]pyrazin-2-yl}-1H-tetrazol-1-yl)acetate

: 1073319-73-9
ethyl (5-{5-[2-(2-bromo-5-fluorophenoxy)ethoxy]pyrazin-2-yl}-2H-tetrazol-2-yl)acetate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; at 90 ℃; for 1h;

Reference yield:

: 1073319-69-3
methyl 5-[2-(2-bromo-5-fluorophenoxy)ethoxy]pyrazine-2-carboxylate

: 1073319-74-0
ethyl (5-{5-[2-(2-bromo-5-fluorophenoxy)ethoxy]pyrazin-2-yl}-1H-tetrazol-1-yl)acetate

Guidance literature:: Multi-step reaction with 4 steps

1: ammonia / tetrahydrofuran; methanol / 5 h / 125 °C

2: N-ethyl-N,N-diisopropylamine; trifluoroacetic anhydride / dichloromethane / -78 - 0 °C

3: sodium azide; ammonium chloride / N,N-dimethyl-formamide / 2 h / 100 °C

4: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 1 h / 90 °C

With sodium azide; ammonia; ammonium chloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic anhydride; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1073318-98-5
2-(2-bromo-5-fluorophenoxy)ethanol

: 1073319-74-0
ethyl (5-{5-[2-(2-bromo-5-fluorophenoxy)ethoxy]pyrazin-2-yl}-1H-tetrazol-1-yl)acetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.33 - 0.5 h / -78 - 20 °C

1.2: 1 h / -78 - 20 °C

2.1: ammonia / tetrahydrofuran; methanol / 5 h / 125 °C

3.1: N-ethyl-N,N-diisopropylamine; trifluoroacetic anhydride / dichloromethane / -78 - 0 °C

4.1: sodium azide; ammonium chloride / N,N-dimethyl-formamide / 2 h / 100 °C

5.1: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 1 h / 90 °C

With sodium azide; ammonia; sodium hydride; ammonium chloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic anhydride; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;