3-(4-chloro-phenyl)-N-methyl-3-pyridin-2-yl-N-[4-(1-trityl-1H-imidazol-4-yl)-butyl]-propionamide

Base Information

• Chemical Name: 3-(4-chloro-phenyl)-N-methyl-3-pyridin-2-yl-N-[4-(1-trityl-1H-imidazol-4-yl)-butyl]-propionamide
• CAS No.: 405551-82-8
• Molecular Formula: C₄₁H₃₉ClN₄O
• Molecular Weight: 639.24

Synonyms:3-(4-chloro-phenyl)-N-methyl-3-pyridin-2-yl-N-[4-(1-trityl-1H-imidazol-4-yl)-butyl]-propionamide

Chemical Property of 3-(4-chloro-phenyl)-N-methyl-3-pyridin-2-yl-N-[4-(1-trityl-1H-imidazol-4-yl)-butyl]-propionamide

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Technology Process of 3-(4-chloro-phenyl)-N-methyl-3-pyridin-2-yl-N-[4-(1-trityl-1H-imidazol-4-yl)-butyl]-propionamide

There total 4 articles about 3-(4-chloro-phenyl)-N-methyl-3-pyridin-2-yl-N-[4-(1-trityl-1H-imidazol-4-yl)-butyl]-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

3-(4-chloro-phenyl)-3-pyridin-2-yl-N-[4-(1-trityl-1H-imidazol-4-yl)-butyl]-propionamide (405551-79-3) + methyl iodide (74-88-4) → 3-(4-chloro-phenyl)-N-methyl-3-pyridin-2-yl-N-[4-(1-trityl-1H-imidazol-4-yl)-butyl]-propionamide (405551-82-8)

Guidance literature:

With sodium hydride; In tetrahydrofuran;

DOI:10.1016/S0960-894X(03)00357-3

Reference yield:

2-(4-chlorobenzoyl)pyridine (6318-51-0) → 3-(4-chloro-phenyl)-N-methyl-3-pyridin-2-yl-N-[4-(1-trityl-1H-imidazol-4-yl)-butyl]-propionamide (405551-82-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 93 percent / NaH / tetrahydrofuran

2: 45 percent / Mg; MeOH

3: 77 percent / Me₃Al / toluene

4: 67 percent / NaH / tetrahydrofuran

With methanol; trimethylaluminum; sodium hydride; magnesium; In tetrahydrofuran; toluene; 1: Wittig olefination;

DOI:10.1016/S0960-894X(03)00357-3

Reference yield:

3-(4-chloro-phenyl)-3-pyridin-2-yl-propionic acid methyl ester (405551-67-9) → 3-(4-chloro-phenyl)-N-methyl-3-pyridin-2-yl-N-[4-(1-trityl-1H-imidazol-4-yl)-butyl]-propionamide (405551-82-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 77 percent / Me₃Al / toluene

2: 67 percent / NaH / tetrahydrofuran

With trimethylaluminum; sodium hydride; In tetrahydrofuran; toluene;

DOI:10.1016/S0960-894X(03)00357-3

upstream raw materials:

3-(4-chloro-phenyl)-3-pyridin-2-yl-N-[4-(1-trityl-1H-imidazol-4-yl)-butyl]-propionamide

methyl iodide

2-(4-chlorobenzoyl)pyridine

(E)-3-(4-Chloro-phenyl)-3-pyridin-2-yl-acrylic acid methyl ester

Downstream raw materials:

[3-(4-chloro-phenyl)-3-pyridin-2-yl-propyl]-methyl-[4-(1-trityl-1H-imidazol-4-yl)-butyl]-amine

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